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Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution

Soft tissue sarcomas (STSs) are a diverse group of rare malignant soft tissue tumors with a high disease burden. Treatment protocols are complex and, to this day, a precise recommendation for the surgical margin width is lacking. The present study aims to analyze the width of the surgical margins in...

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Autores principales: Wittenberg, Silvan, Paraskevaidis, Melissa, Jarosch, Armin, Flörcken, Anne, Brandes, Franziska, Striefler, Jana, Kaul, David, Roohani, Siyer, Khakzad, Thilo, Märdian, Sven, Rau, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695590/
https://www.ncbi.nlm.nih.gov/pubmed/36362849
http://dx.doi.org/10.3390/life12111694
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author Wittenberg, Silvan
Paraskevaidis, Melissa
Jarosch, Armin
Flörcken, Anne
Brandes, Franziska
Striefler, Jana
Kaul, David
Roohani, Siyer
Khakzad, Thilo
Märdian, Sven
Rau, Daniel
author_facet Wittenberg, Silvan
Paraskevaidis, Melissa
Jarosch, Armin
Flörcken, Anne
Brandes, Franziska
Striefler, Jana
Kaul, David
Roohani, Siyer
Khakzad, Thilo
Märdian, Sven
Rau, Daniel
author_sort Wittenberg, Silvan
collection PubMed
description Soft tissue sarcomas (STSs) are a diverse group of rare malignant soft tissue tumors with a high disease burden. Treatment protocols are complex and, to this day, a precise recommendation for the surgical margin width is lacking. The present study aims to analyze the width of the surgical margins in STS resection specimens and analyze them for local and systemic disease-free survival as well as for most frequent histologic STS subtypes. A total of 169 consecutive patients diagnosed and treated in curative intent in our institution following a primary and localized STS of the extremities or trunk from January 2010 to December 2020 were included in this study regardless of age. Our data reveal that low-grade STSs are best controlled locally by a surgical margin ≥2 mm and in this way also preventing distant metastases effectively. Local recurrence-free survival and metastasis-free survival in high-grade STS were improved by intact muscle fascia or periosteum at the margin when compared only to soft tissue. However, the outcome was independent of the surgical margin width, suggesting a close but negative margin may be safe in high-grade STS subtypes with less invasive growth patterns when combined with adjunct radiochemotherapy.
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spelling pubmed-96955902022-11-26 Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution Wittenberg, Silvan Paraskevaidis, Melissa Jarosch, Armin Flörcken, Anne Brandes, Franziska Striefler, Jana Kaul, David Roohani, Siyer Khakzad, Thilo Märdian, Sven Rau, Daniel Life (Basel) Article Soft tissue sarcomas (STSs) are a diverse group of rare malignant soft tissue tumors with a high disease burden. Treatment protocols are complex and, to this day, a precise recommendation for the surgical margin width is lacking. The present study aims to analyze the width of the surgical margins in STS resection specimens and analyze them for local and systemic disease-free survival as well as for most frequent histologic STS subtypes. A total of 169 consecutive patients diagnosed and treated in curative intent in our institution following a primary and localized STS of the extremities or trunk from January 2010 to December 2020 were included in this study regardless of age. Our data reveal that low-grade STSs are best controlled locally by a surgical margin ≥2 mm and in this way also preventing distant metastases effectively. Local recurrence-free survival and metastasis-free survival in high-grade STS were improved by intact muscle fascia or periosteum at the margin when compared only to soft tissue. However, the outcome was independent of the surgical margin width, suggesting a close but negative margin may be safe in high-grade STS subtypes with less invasive growth patterns when combined with adjunct radiochemotherapy. MDPI 2022-10-25 /pmc/articles/PMC9695590/ /pubmed/36362849 http://dx.doi.org/10.3390/life12111694 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wittenberg, Silvan
Paraskevaidis, Melissa
Jarosch, Armin
Flörcken, Anne
Brandes, Franziska
Striefler, Jana
Kaul, David
Roohani, Siyer
Khakzad, Thilo
Märdian, Sven
Rau, Daniel
Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title_full Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title_fullStr Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title_full_unstemmed Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title_short Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
title_sort surgical margins in soft tissue sarcoma management and corresponding local and systemic recurrence rates: a retrospective study covering 11 years and 169 patients in a single institution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695590/
https://www.ncbi.nlm.nih.gov/pubmed/36362849
http://dx.doi.org/10.3390/life12111694
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