Cargando…

SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron

With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (an...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Brien, Sheila F., Caffrey, Niamh, Yi, Qi-Long, Pambrun, Chantale, Drews, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695729/
https://www.ncbi.nlm.nih.gov/pubmed/36366432
http://dx.doi.org/10.3390/v14112336
_version_ 1784838135457251328
author O’Brien, Sheila F.
Caffrey, Niamh
Yi, Qi-Long
Pambrun, Chantale
Drews, Steven J.
author_facet O’Brien, Sheila F.
Caffrey, Niamh
Yi, Qi-Long
Pambrun, Chantale
Drews, Steven J.
author_sort O’Brien, Sheila F.
collection PubMed
description With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 randomly selected samples. Multivariable logistic regression of anti-N positivity with month, age, sex, racialization, region, material and social deprivation (based on postal code) identified as independent predictors. Piece-wise logistic regression analysed the association between anti-S concentration and month, and anti-N/anti-S positivity. Infection-related seroprevalence (anti-N positive) was 4.38% (95% CI: 3.96, 4.81) in September reaching 50.70% (50.15, 52.16) in June; nearly 100% were anti-S positive throughout. Anti-N positivity was associated with younger age, male sex, the Alberta and Prairies regions, greater material deprivation and less social deprivation (p < 0.001). Anti-S concentration was high initially (3306 U/mL, IQR 4280 U/mL), increased to (13,659 U/mL, IQR 28,224 U/mL) by June (p < 0.001), following the pattern of deployment of the third and fourth vaccine doses and was higher in those that were anti-N positive (p < 0.001). Despite already high vaccination-related seroprevalence, infection-related seroprevalence increased dramatically with the emergence of the Omicron SARS-CoV-2 variant.
format Online
Article
Text
id pubmed-9695729
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96957292022-11-26 SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron O’Brien, Sheila F. Caffrey, Niamh Yi, Qi-Long Pambrun, Chantale Drews, Steven J. Viruses Article With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 randomly selected samples. Multivariable logistic regression of anti-N positivity with month, age, sex, racialization, region, material and social deprivation (based on postal code) identified as independent predictors. Piece-wise logistic regression analysed the association between anti-S concentration and month, and anti-N/anti-S positivity. Infection-related seroprevalence (anti-N positive) was 4.38% (95% CI: 3.96, 4.81) in September reaching 50.70% (50.15, 52.16) in June; nearly 100% were anti-S positive throughout. Anti-N positivity was associated with younger age, male sex, the Alberta and Prairies regions, greater material deprivation and less social deprivation (p < 0.001). Anti-S concentration was high initially (3306 U/mL, IQR 4280 U/mL), increased to (13,659 U/mL, IQR 28,224 U/mL) by June (p < 0.001), following the pattern of deployment of the third and fourth vaccine doses and was higher in those that were anti-N positive (p < 0.001). Despite already high vaccination-related seroprevalence, infection-related seroprevalence increased dramatically with the emergence of the Omicron SARS-CoV-2 variant. MDPI 2022-10-25 /pmc/articles/PMC9695729/ /pubmed/36366432 http://dx.doi.org/10.3390/v14112336 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
O’Brien, Sheila F.
Caffrey, Niamh
Yi, Qi-Long
Pambrun, Chantale
Drews, Steven J.
SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title_full SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title_fullStr SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title_full_unstemmed SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title_short SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
title_sort sars-cov-2 seroprevalence among canadian blood donors: the advance of omicron
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695729/
https://www.ncbi.nlm.nih.gov/pubmed/36366432
http://dx.doi.org/10.3390/v14112336
work_keys_str_mv AT obriensheilaf sarscov2seroprevalenceamongcanadianblooddonorstheadvanceofomicron
AT caffreyniamh sarscov2seroprevalenceamongcanadianblooddonorstheadvanceofomicron
AT yiqilong sarscov2seroprevalenceamongcanadianblooddonorstheadvanceofomicron
AT pambrunchantale sarscov2seroprevalenceamongcanadianblooddonorstheadvanceofomicron
AT drewsstevenj sarscov2seroprevalenceamongcanadianblooddonorstheadvanceofomicron