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SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron
With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695729/ https://www.ncbi.nlm.nih.gov/pubmed/36366432 http://dx.doi.org/10.3390/v14112336 |
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author | O’Brien, Sheila F. Caffrey, Niamh Yi, Qi-Long Pambrun, Chantale Drews, Steven J. |
author_facet | O’Brien, Sheila F. Caffrey, Niamh Yi, Qi-Long Pambrun, Chantale Drews, Steven J. |
author_sort | O’Brien, Sheila F. |
collection | PubMed |
description | With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 randomly selected samples. Multivariable logistic regression of anti-N positivity with month, age, sex, racialization, region, material and social deprivation (based on postal code) identified as independent predictors. Piece-wise logistic regression analysed the association between anti-S concentration and month, and anti-N/anti-S positivity. Infection-related seroprevalence (anti-N positive) was 4.38% (95% CI: 3.96, 4.81) in September reaching 50.70% (50.15, 52.16) in June; nearly 100% were anti-S positive throughout. Anti-N positivity was associated with younger age, male sex, the Alberta and Prairies regions, greater material deprivation and less social deprivation (p < 0.001). Anti-S concentration was high initially (3306 U/mL, IQR 4280 U/mL), increased to (13,659 U/mL, IQR 28,224 U/mL) by June (p < 0.001), following the pattern of deployment of the third and fourth vaccine doses and was higher in those that were anti-N positive (p < 0.001). Despite already high vaccination-related seroprevalence, infection-related seroprevalence increased dramatically with the emergence of the Omicron SARS-CoV-2 variant. |
format | Online Article Text |
id | pubmed-9695729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96957292022-11-26 SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron O’Brien, Sheila F. Caffrey, Niamh Yi, Qi-Long Pambrun, Chantale Drews, Steven J. Viruses Article With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 randomly selected samples. Multivariable logistic regression of anti-N positivity with month, age, sex, racialization, region, material and social deprivation (based on postal code) identified as independent predictors. Piece-wise logistic regression analysed the association between anti-S concentration and month, and anti-N/anti-S positivity. Infection-related seroprevalence (anti-N positive) was 4.38% (95% CI: 3.96, 4.81) in September reaching 50.70% (50.15, 52.16) in June; nearly 100% were anti-S positive throughout. Anti-N positivity was associated with younger age, male sex, the Alberta and Prairies regions, greater material deprivation and less social deprivation (p < 0.001). Anti-S concentration was high initially (3306 U/mL, IQR 4280 U/mL), increased to (13,659 U/mL, IQR 28,224 U/mL) by June (p < 0.001), following the pattern of deployment of the third and fourth vaccine doses and was higher in those that were anti-N positive (p < 0.001). Despite already high vaccination-related seroprevalence, infection-related seroprevalence increased dramatically with the emergence of the Omicron SARS-CoV-2 variant. MDPI 2022-10-25 /pmc/articles/PMC9695729/ /pubmed/36366432 http://dx.doi.org/10.3390/v14112336 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article O’Brien, Sheila F. Caffrey, Niamh Yi, Qi-Long Pambrun, Chantale Drews, Steven J. SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title | SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title_full | SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title_fullStr | SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title_full_unstemmed | SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title_short | SARS-CoV-2 Seroprevalence among Canadian Blood Donors: The Advance of Omicron |
title_sort | sars-cov-2 seroprevalence among canadian blood donors: the advance of omicron |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695729/ https://www.ncbi.nlm.nih.gov/pubmed/36366432 http://dx.doi.org/10.3390/v14112336 |
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