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Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae

Cistus salviifolius has been previously reported as a traditional remedy for hyperglycemia. However, the plant has been scarcely investigated from scientific point of view. Thus, the aim was to examine the chemical composition and to evaluate its antioxidant and antihyperglycemic potential in vitro....

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Autores principales: Hitl, Maja, Bijelić, Katarina, Stilinović, Nebojša, Božin, Biljana, Srđenović-Čonić, Branislava, Torović, Ljilja, Kladar, Nebojša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695765/
https://www.ncbi.nlm.nih.gov/pubmed/36432103
http://dx.doi.org/10.3390/molecules27228003
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author Hitl, Maja
Bijelić, Katarina
Stilinović, Nebojša
Božin, Biljana
Srđenović-Čonić, Branislava
Torović, Ljilja
Kladar, Nebojša
author_facet Hitl, Maja
Bijelić, Katarina
Stilinović, Nebojša
Božin, Biljana
Srđenović-Čonić, Branislava
Torović, Ljilja
Kladar, Nebojša
author_sort Hitl, Maja
collection PubMed
description Cistus salviifolius has been previously reported as a traditional remedy for hyperglycemia. However, the plant has been scarcely investigated from scientific point of view. Thus, the aim was to examine the chemical composition and to evaluate its antioxidant and antihyperglycemic potential in vitro. Aqueous and ethanolic extracts were evaluated for total phenolic, tannin, and flavonoid content using spectrophotometric methods. Detailed chemical characterization was performed by high-performance liquid chromatography (HPLC-DAD). The volatile organic compounds (VOCs) profile was assessed by gas chromatography technique. The potential in diabetes treatment was evaluated through tests of free radicals neutralization, inhibition of lipid peroxidation process, and test of ferric ion reduction; activity in tests of inhibition of α-amylase, α-glucosidase and dipeptidyl peptidase-4 was also evaluated. High content of phenolics (majority being tannins) was detected; detailed HPLC analysis revealed high content of gallic acid, followed by rutin, chlorogenic and caffeic acids. The VOCs analysis determined sesquiterpene hydrocarbons and oxygenated sesquiterpenes as the main groups of compounds. The assays classified extracts as potent neutralizers of 2,2-diphenyl-1-picrylhydrazil and nitroso radicals formation and potent inhibitors of α-amylase and α-glucosidase. In conclusion, Cistus salviifolius represents a rich source of phenolics and essential oil with sesquiterpenes. The established results suggested its promising antioxidant and antihyperglycemic activities.
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spelling pubmed-96957652022-11-26 Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae Hitl, Maja Bijelić, Katarina Stilinović, Nebojša Božin, Biljana Srđenović-Čonić, Branislava Torović, Ljilja Kladar, Nebojša Molecules Article Cistus salviifolius has been previously reported as a traditional remedy for hyperglycemia. However, the plant has been scarcely investigated from scientific point of view. Thus, the aim was to examine the chemical composition and to evaluate its antioxidant and antihyperglycemic potential in vitro. Aqueous and ethanolic extracts were evaluated for total phenolic, tannin, and flavonoid content using spectrophotometric methods. Detailed chemical characterization was performed by high-performance liquid chromatography (HPLC-DAD). The volatile organic compounds (VOCs) profile was assessed by gas chromatography technique. The potential in diabetes treatment was evaluated through tests of free radicals neutralization, inhibition of lipid peroxidation process, and test of ferric ion reduction; activity in tests of inhibition of α-amylase, α-glucosidase and dipeptidyl peptidase-4 was also evaluated. High content of phenolics (majority being tannins) was detected; detailed HPLC analysis revealed high content of gallic acid, followed by rutin, chlorogenic and caffeic acids. The VOCs analysis determined sesquiterpene hydrocarbons and oxygenated sesquiterpenes as the main groups of compounds. The assays classified extracts as potent neutralizers of 2,2-diphenyl-1-picrylhydrazil and nitroso radicals formation and potent inhibitors of α-amylase and α-glucosidase. In conclusion, Cistus salviifolius represents a rich source of phenolics and essential oil with sesquiterpenes. The established results suggested its promising antioxidant and antihyperglycemic activities. MDPI 2022-11-18 /pmc/articles/PMC9695765/ /pubmed/36432103 http://dx.doi.org/10.3390/molecules27228003 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hitl, Maja
Bijelić, Katarina
Stilinović, Nebojša
Božin, Biljana
Srđenović-Čonić, Branislava
Torović, Ljilja
Kladar, Nebojša
Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title_full Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title_fullStr Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title_full_unstemmed Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title_short Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae
title_sort phytochemistry and antihyperglycemic potential of cistus salviifolius l., cistaceae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695765/
https://www.ncbi.nlm.nih.gov/pubmed/36432103
http://dx.doi.org/10.3390/molecules27228003
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