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The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review

Prompt detection and isolation of COVID-19 cases is vital for preventing further viral transmission, and lateral flow or rapid antigen tests have been an important diagnostic tool in this pandemic. However, concerns have emerged regarding the sensitivity of these devices for the new BA.1, BA.2, and...

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Autores principales: Ng, Qin Xiang, Lim, Yu Liang, Han, Ming Xuan, Teoh, Seth En, Thumboo, Julian, Tan, Ban Hock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695766/
https://www.ncbi.nlm.nih.gov/pubmed/36431077
http://dx.doi.org/10.3390/life12111941
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author Ng, Qin Xiang
Lim, Yu Liang
Han, Ming Xuan
Teoh, Seth En
Thumboo, Julian
Tan, Ban Hock
author_facet Ng, Qin Xiang
Lim, Yu Liang
Han, Ming Xuan
Teoh, Seth En
Thumboo, Julian
Tan, Ban Hock
author_sort Ng, Qin Xiang
collection PubMed
description Prompt detection and isolation of COVID-19 cases is vital for preventing further viral transmission, and lateral flow or rapid antigen tests have been an important diagnostic tool in this pandemic. However, concerns have emerged regarding the sensitivity of these devices for the new BA.1, BA.2, and BA.4/5 omicron variants, which have greater transmissibility and extensive mutations in its spike (S) and nucleocapsid (N) proteins. N protein is an important target protein for existing lateral flow devices. This paper therefore aimed to provide a rapid review of available literature on the performance of the lateral flow tests for detecting the omicron coronavirus variant. A systematic literature search of PubMed, EMBASE, OVID Medline, and Google Scholar found six published studies and four preprints investigating the performance of existing lateral flow devices for the omicron variant, as compared to the B.1.617.2 (Delta) variant. Overall, it appears that the devices have poorer performance for the omicron variant and when testing samples with cycle threshold (Ct) values greater than 25 and in asymptomatic individuals. As most available data were preliminary and had small sample sizes, it is recommended that these data be further studied to better inform and adapt our public health responses.
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spelling pubmed-96957662022-11-26 The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review Ng, Qin Xiang Lim, Yu Liang Han, Ming Xuan Teoh, Seth En Thumboo, Julian Tan, Ban Hock Life (Basel) Systematic Review Prompt detection and isolation of COVID-19 cases is vital for preventing further viral transmission, and lateral flow or rapid antigen tests have been an important diagnostic tool in this pandemic. However, concerns have emerged regarding the sensitivity of these devices for the new BA.1, BA.2, and BA.4/5 omicron variants, which have greater transmissibility and extensive mutations in its spike (S) and nucleocapsid (N) proteins. N protein is an important target protein for existing lateral flow devices. This paper therefore aimed to provide a rapid review of available literature on the performance of the lateral flow tests for detecting the omicron coronavirus variant. A systematic literature search of PubMed, EMBASE, OVID Medline, and Google Scholar found six published studies and four preprints investigating the performance of existing lateral flow devices for the omicron variant, as compared to the B.1.617.2 (Delta) variant. Overall, it appears that the devices have poorer performance for the omicron variant and when testing samples with cycle threshold (Ct) values greater than 25 and in asymptomatic individuals. As most available data were preliminary and had small sample sizes, it is recommended that these data be further studied to better inform and adapt our public health responses. MDPI 2022-11-21 /pmc/articles/PMC9695766/ /pubmed/36431077 http://dx.doi.org/10.3390/life12111941 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ng, Qin Xiang
Lim, Yu Liang
Han, Ming Xuan
Teoh, Seth En
Thumboo, Julian
Tan, Ban Hock
The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title_full The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title_fullStr The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title_full_unstemmed The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title_short The Performance of Lateral Flow Tests in the Age of the Omicron: A Rapid Systematic Review
title_sort performance of lateral flow tests in the age of the omicron: a rapid systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695766/
https://www.ncbi.nlm.nih.gov/pubmed/36431077
http://dx.doi.org/10.3390/life12111941
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