High Throughput Sequencing for Clinical Tuberculosis: An Overview

High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical application of HTS for TB diagnosis. The workflow challenges,...

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Detalles Bibliográficos
Autores principales: Ness, Tara E., DiNardo, Andrew, Farhat, Maha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695813/
https://www.ncbi.nlm.nih.gov/pubmed/36422596
http://dx.doi.org/10.3390/pathogens11111343
Descripción
Sumario:High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical application of HTS for TB diagnosis. The workflow challenges, strengths and limitations of the various sequencing platforms, and tools used for analysis are presented to provide a framework for further innovations in the field.

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