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Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and figh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695907/ https://www.ncbi.nlm.nih.gov/pubmed/36363634 http://dx.doi.org/10.3390/membranes12111079 |
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author | Jasni, Nurhana Saidin, Syazwan Kin, Wong Weng Arifin, Norsyahida Othman, Nurulhasanah |
author_facet | Jasni, Nurhana Saidin, Syazwan Kin, Wong Weng Arifin, Norsyahida Othman, Nurulhasanah |
author_sort | Jasni, Nurhana |
collection | PubMed |
description | Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and fighting against substances it sees as harmful or foreign. E. histolytica biological membranes are considered foreign and immunogenic to the human body, thereby initiating the body's immune responses. Understanding immune response and antigen interaction are essential for vaccine development. Thus, this review aims to identify and understand the protein structure, function, and interaction of the biological membrane with the immune response, which could contribute to vaccine development. Furthermore, the current trend of vaccine development studies to combat amoebiasis is also reviewed. |
format | Online Article Text |
id | pubmed-9695907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96959072022-11-26 Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development Jasni, Nurhana Saidin, Syazwan Kin, Wong Weng Arifin, Norsyahida Othman, Nurulhasanah Membranes (Basel) Review Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and fighting against substances it sees as harmful or foreign. E. histolytica biological membranes are considered foreign and immunogenic to the human body, thereby initiating the body's immune responses. Understanding immune response and antigen interaction are essential for vaccine development. Thus, this review aims to identify and understand the protein structure, function, and interaction of the biological membrane with the immune response, which could contribute to vaccine development. Furthermore, the current trend of vaccine development studies to combat amoebiasis is also reviewed. MDPI 2022-10-31 /pmc/articles/PMC9695907/ /pubmed/36363634 http://dx.doi.org/10.3390/membranes12111079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jasni, Nurhana Saidin, Syazwan Kin, Wong Weng Arifin, Norsyahida Othman, Nurulhasanah Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title | Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title_full | Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title_fullStr | Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title_full_unstemmed | Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title_short | Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development |
title_sort | entamoeba histolytica: membrane and non-membrane protein structure, function, immune response interaction, and vaccine development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695907/ https://www.ncbi.nlm.nih.gov/pubmed/36363634 http://dx.doi.org/10.3390/membranes12111079 |
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