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Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development

Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and figh...

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Autores principales: Jasni, Nurhana, Saidin, Syazwan, Kin, Wong Weng, Arifin, Norsyahida, Othman, Nurulhasanah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695907/
https://www.ncbi.nlm.nih.gov/pubmed/36363634
http://dx.doi.org/10.3390/membranes12111079
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author Jasni, Nurhana
Saidin, Syazwan
Kin, Wong Weng
Arifin, Norsyahida
Othman, Nurulhasanah
author_facet Jasni, Nurhana
Saidin, Syazwan
Kin, Wong Weng
Arifin, Norsyahida
Othman, Nurulhasanah
author_sort Jasni, Nurhana
collection PubMed
description Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and fighting against substances it sees as harmful or foreign. E. histolytica biological membranes are considered foreign and immunogenic to the human body, thereby initiating the body's immune responses. Understanding immune response and antigen interaction are essential for vaccine development. Thus, this review aims to identify and understand the protein structure, function, and interaction of the biological membrane with the immune response, which could contribute to vaccine development. Furthermore, the current trend of vaccine development studies to combat amoebiasis is also reviewed.
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spelling pubmed-96959072022-11-26 Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development Jasni, Nurhana Saidin, Syazwan Kin, Wong Weng Arifin, Norsyahida Othman, Nurulhasanah Membranes (Basel) Review Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and fighting against substances it sees as harmful or foreign. E. histolytica biological membranes are considered foreign and immunogenic to the human body, thereby initiating the body's immune responses. Understanding immune response and antigen interaction are essential for vaccine development. Thus, this review aims to identify and understand the protein structure, function, and interaction of the biological membrane with the immune response, which could contribute to vaccine development. Furthermore, the current trend of vaccine development studies to combat amoebiasis is also reviewed. MDPI 2022-10-31 /pmc/articles/PMC9695907/ /pubmed/36363634 http://dx.doi.org/10.3390/membranes12111079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jasni, Nurhana
Saidin, Syazwan
Kin, Wong Weng
Arifin, Norsyahida
Othman, Nurulhasanah
Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title_full Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title_fullStr Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title_full_unstemmed Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title_short Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development
title_sort entamoeba histolytica: membrane and non-membrane protein structure, function, immune response interaction, and vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695907/
https://www.ncbi.nlm.nih.gov/pubmed/36363634
http://dx.doi.org/10.3390/membranes12111079
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