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Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion

The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was...

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Autores principales: Kishimoto, Ichiro, Ohashi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695914/
https://www.ncbi.nlm.nih.gov/pubmed/36355105
http://dx.doi.org/10.3390/metabo12111022
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author Kishimoto, Ichiro
Ohashi, Akio
author_facet Kishimoto, Ichiro
Ohashi, Akio
author_sort Kishimoto, Ichiro
collection PubMed
description The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was significantly associated with 1,5-anhydroglycitol, a biochemical marker for postprandial hyperglycemia. The receiver operating characteristic analyses of SgIo and oral disposition index for detecting the subjects with 1,5-anhydroglycitol < 14 μg/mL revealed that the areas under the curves were 0.77 and 0.76, while the cutoff points (sensitivity, selectivity) were 2.53 (0.9, 0.7) and 2.06 (0.36, 0.79), respectively. Both the SgIo < 2.53 category and the disposition index < 2.06 category were significantly associated with the percentages of meals with postprandial glucose levels ≥ 200 mg/dL, and the percentages of time when continuous glucose monitoring sensor readings were ≥200 mg/dL. After adjustment with disposition index, 45.5% of the subjects with the SgIo < 2.53 category had their 1,5-anhydroglycitol < 14 μg/mL, while, in the SgIo ≥ 2.53 category, 3.6% of the subjects had the hyperglycemia (p < 0.001). In addition, there were tendencies toward higher and lower SgIo quartile categories in subjects with walking (≥8000 steps) ≥60% of days and with noodle ingestion ≥20% of meals, respectively (p for trend, 0.008 and 0.038). In conclusion, lower glucose effectiveness is associated with postprandial hyperglycemia in the daily life of obese/overweight men, independently of insulin secretion. Lifestyles such as habits of walking and noodle ingestion are significantly associated with higher and lower glucose effectiveness, respectively.
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spelling pubmed-96959142022-11-26 Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion Kishimoto, Ichiro Ohashi, Akio Metabolites Article The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was significantly associated with 1,5-anhydroglycitol, a biochemical marker for postprandial hyperglycemia. The receiver operating characteristic analyses of SgIo and oral disposition index for detecting the subjects with 1,5-anhydroglycitol < 14 μg/mL revealed that the areas under the curves were 0.77 and 0.76, while the cutoff points (sensitivity, selectivity) were 2.53 (0.9, 0.7) and 2.06 (0.36, 0.79), respectively. Both the SgIo < 2.53 category and the disposition index < 2.06 category were significantly associated with the percentages of meals with postprandial glucose levels ≥ 200 mg/dL, and the percentages of time when continuous glucose monitoring sensor readings were ≥200 mg/dL. After adjustment with disposition index, 45.5% of the subjects with the SgIo < 2.53 category had their 1,5-anhydroglycitol < 14 μg/mL, while, in the SgIo ≥ 2.53 category, 3.6% of the subjects had the hyperglycemia (p < 0.001). In addition, there were tendencies toward higher and lower SgIo quartile categories in subjects with walking (≥8000 steps) ≥60% of days and with noodle ingestion ≥20% of meals, respectively (p for trend, 0.008 and 0.038). In conclusion, lower glucose effectiveness is associated with postprandial hyperglycemia in the daily life of obese/overweight men, independently of insulin secretion. Lifestyles such as habits of walking and noodle ingestion are significantly associated with higher and lower glucose effectiveness, respectively. MDPI 2022-10-25 /pmc/articles/PMC9695914/ /pubmed/36355105 http://dx.doi.org/10.3390/metabo12111022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kishimoto, Ichiro
Ohashi, Akio
Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title_full Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title_fullStr Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title_full_unstemmed Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title_short Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
title_sort lower glucose effectiveness is associated with postprandial hyperglycemia in obese/overweight men, independently of insulin secretion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695914/
https://www.ncbi.nlm.nih.gov/pubmed/36355105
http://dx.doi.org/10.3390/metabo12111022
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