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Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion
The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695914/ https://www.ncbi.nlm.nih.gov/pubmed/36355105 http://dx.doi.org/10.3390/metabo12111022 |
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author | Kishimoto, Ichiro Ohashi, Akio |
author_facet | Kishimoto, Ichiro Ohashi, Akio |
author_sort | Kishimoto, Ichiro |
collection | PubMed |
description | The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was significantly associated with 1,5-anhydroglycitol, a biochemical marker for postprandial hyperglycemia. The receiver operating characteristic analyses of SgIo and oral disposition index for detecting the subjects with 1,5-anhydroglycitol < 14 μg/mL revealed that the areas under the curves were 0.77 and 0.76, while the cutoff points (sensitivity, selectivity) were 2.53 (0.9, 0.7) and 2.06 (0.36, 0.79), respectively. Both the SgIo < 2.53 category and the disposition index < 2.06 category were significantly associated with the percentages of meals with postprandial glucose levels ≥ 200 mg/dL, and the percentages of time when continuous glucose monitoring sensor readings were ≥200 mg/dL. After adjustment with disposition index, 45.5% of the subjects with the SgIo < 2.53 category had their 1,5-anhydroglycitol < 14 μg/mL, while, in the SgIo ≥ 2.53 category, 3.6% of the subjects had the hyperglycemia (p < 0.001). In addition, there were tendencies toward higher and lower SgIo quartile categories in subjects with walking (≥8000 steps) ≥60% of days and with noodle ingestion ≥20% of meals, respectively (p for trend, 0.008 and 0.038). In conclusion, lower glucose effectiveness is associated with postprandial hyperglycemia in the daily life of obese/overweight men, independently of insulin secretion. Lifestyles such as habits of walking and noodle ingestion are significantly associated with higher and lower glucose effectiveness, respectively. |
format | Online Article Text |
id | pubmed-9695914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96959142022-11-26 Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion Kishimoto, Ichiro Ohashi, Akio Metabolites Article The role of glucose effectiveness on postprandial hyperglycemia in daily life is not fully studied. Here, we examined the association between SgIo, an index of glucose effectiveness calculated from a 75 g oral glucose tolerance test, and the indices of hyperglycemia in obese/overweight men. SgIo was significantly associated with 1,5-anhydroglycitol, a biochemical marker for postprandial hyperglycemia. The receiver operating characteristic analyses of SgIo and oral disposition index for detecting the subjects with 1,5-anhydroglycitol < 14 μg/mL revealed that the areas under the curves were 0.77 and 0.76, while the cutoff points (sensitivity, selectivity) were 2.53 (0.9, 0.7) and 2.06 (0.36, 0.79), respectively. Both the SgIo < 2.53 category and the disposition index < 2.06 category were significantly associated with the percentages of meals with postprandial glucose levels ≥ 200 mg/dL, and the percentages of time when continuous glucose monitoring sensor readings were ≥200 mg/dL. After adjustment with disposition index, 45.5% of the subjects with the SgIo < 2.53 category had their 1,5-anhydroglycitol < 14 μg/mL, while, in the SgIo ≥ 2.53 category, 3.6% of the subjects had the hyperglycemia (p < 0.001). In addition, there were tendencies toward higher and lower SgIo quartile categories in subjects with walking (≥8000 steps) ≥60% of days and with noodle ingestion ≥20% of meals, respectively (p for trend, 0.008 and 0.038). In conclusion, lower glucose effectiveness is associated with postprandial hyperglycemia in the daily life of obese/overweight men, independently of insulin secretion. Lifestyles such as habits of walking and noodle ingestion are significantly associated with higher and lower glucose effectiveness, respectively. MDPI 2022-10-25 /pmc/articles/PMC9695914/ /pubmed/36355105 http://dx.doi.org/10.3390/metabo12111022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kishimoto, Ichiro Ohashi, Akio Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title | Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title_full | Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title_fullStr | Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title_full_unstemmed | Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title_short | Lower Glucose Effectiveness Is Associated with Postprandial Hyperglycemia in Obese/Overweight Men, Independently of Insulin Secretion |
title_sort | lower glucose effectiveness is associated with postprandial hyperglycemia in obese/overweight men, independently of insulin secretion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695914/ https://www.ncbi.nlm.nih.gov/pubmed/36355105 http://dx.doi.org/10.3390/metabo12111022 |
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