The Role of the Cutaneous Mycobiome in Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed myco...

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Autores principales: Szczepańska, Milena, Blicharz, Leszek, Nowaczyk, Joanna, Makowska, Karolina, Goldust, Mohamad, Waśkiel-Burnat, Anna, Czuwara, Joanna, Samochocki, Zbigniew, Rudnicka, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695942/
https://www.ncbi.nlm.nih.gov/pubmed/36354920
http://dx.doi.org/10.3390/jof8111153
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author Szczepańska, Milena
Blicharz, Leszek
Nowaczyk, Joanna
Makowska, Karolina
Goldust, Mohamad
Waśkiel-Burnat, Anna
Czuwara, Joanna
Samochocki, Zbigniew
Rudnicka, Lidia
author_facet Szczepańska, Milena
Blicharz, Leszek
Nowaczyk, Joanna
Makowska, Karolina
Goldust, Mohamad
Waśkiel-Burnat, Anna
Czuwara, Joanna
Samochocki, Zbigniew
Rudnicka, Lidia
author_sort Szczepańska, Milena
collection PubMed
description Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed mycobiome) appear to be an important factor influencing the clinical picture of this entity. This review summarizes the available insights into the role of the cutaneous mycobiome in atopic dermatitis and the new research possibilities in this field. The prevalence and characteristics of key fungal species, the most important pathogenesis pathways, as well as classic and emerging therapies of fungal dysbiosis and infections complicating atopic dermatitis, are presented.
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spelling pubmed-96959422022-11-26 The Role of the Cutaneous Mycobiome in Atopic Dermatitis Szczepańska, Milena Blicharz, Leszek Nowaczyk, Joanna Makowska, Karolina Goldust, Mohamad Waśkiel-Burnat, Anna Czuwara, Joanna Samochocki, Zbigniew Rudnicka, Lidia J Fungi (Basel) Review Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed mycobiome) appear to be an important factor influencing the clinical picture of this entity. This review summarizes the available insights into the role of the cutaneous mycobiome in atopic dermatitis and the new research possibilities in this field. The prevalence and characteristics of key fungal species, the most important pathogenesis pathways, as well as classic and emerging therapies of fungal dysbiosis and infections complicating atopic dermatitis, are presented. MDPI 2022-10-31 /pmc/articles/PMC9695942/ /pubmed/36354920 http://dx.doi.org/10.3390/jof8111153 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szczepańska, Milena
Blicharz, Leszek
Nowaczyk, Joanna
Makowska, Karolina
Goldust, Mohamad
Waśkiel-Burnat, Anna
Czuwara, Joanna
Samochocki, Zbigniew
Rudnicka, Lidia
The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title_full The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title_fullStr The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title_full_unstemmed The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title_short The Role of the Cutaneous Mycobiome in Atopic Dermatitis
title_sort role of the cutaneous mycobiome in atopic dermatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695942/
https://www.ncbi.nlm.nih.gov/pubmed/36354920
http://dx.doi.org/10.3390/jof8111153
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