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The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. Furthermore, FXR represents a real guardian of the hepatic function, preserving, in a multifactorial fash...

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Autores principales: Rausch, Magdalena, Samodelov, Sophia L., Visentin, Michele, Kullak-Ublick, Gerd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695947/
https://www.ncbi.nlm.nih.gov/pubmed/36430444
http://dx.doi.org/10.3390/ijms232213967
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author Rausch, Magdalena
Samodelov, Sophia L.
Visentin, Michele
Kullak-Ublick, Gerd A.
author_facet Rausch, Magdalena
Samodelov, Sophia L.
Visentin, Michele
Kullak-Ublick, Gerd A.
author_sort Rausch, Magdalena
collection PubMed
description The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. Furthermore, FXR represents a real guardian of the hepatic function, preserving, in a multifactorial fashion, the integrity and function of hepatocytes from chronic and acute insults. This review summarizes how FXR modulates the expression of pathway-specific as well as polyspecific transporters and enzymes, thereby acting at the interface of BA, lipid and drug metabolism, and influencing the onset and progression of hepatotoxicity of varying etiopathogeneses. Furthermore, this review article provides an overview of the advances and the clinical development of FXR agonists in the treatment of liver diseases.
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spelling pubmed-96959472022-11-26 The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity Rausch, Magdalena Samodelov, Sophia L. Visentin, Michele Kullak-Ublick, Gerd A. Int J Mol Sci Review The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. Furthermore, FXR represents a real guardian of the hepatic function, preserving, in a multifactorial fashion, the integrity and function of hepatocytes from chronic and acute insults. This review summarizes how FXR modulates the expression of pathway-specific as well as polyspecific transporters and enzymes, thereby acting at the interface of BA, lipid and drug metabolism, and influencing the onset and progression of hepatotoxicity of varying etiopathogeneses. Furthermore, this review article provides an overview of the advances and the clinical development of FXR agonists in the treatment of liver diseases. MDPI 2022-11-12 /pmc/articles/PMC9695947/ /pubmed/36430444 http://dx.doi.org/10.3390/ijms232213967 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rausch, Magdalena
Samodelov, Sophia L.
Visentin, Michele
Kullak-Ublick, Gerd A.
The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title_full The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title_fullStr The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title_full_unstemmed The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title_short The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
title_sort farnesoid x receptor as a master regulator of hepatotoxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695947/
https://www.ncbi.nlm.nih.gov/pubmed/36430444
http://dx.doi.org/10.3390/ijms232213967
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