Cargando…

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. Furthermore, FXR represents a real guardian of the hepatic function, preserving, in a multifactorial fash...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rausch, Magdalena, Samodelov, Sophia L., Visentin, Michele, Kullak-Ublick, Gerd A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695947/ https://www.ncbi.nlm.nih.gov/pubmed/36430444 http://dx.doi.org/10.3390/ijms232213967

Ejemplares similares

Molecular Mechanisms of Colistin-Induced Nephrotoxicity
por: Gai, Zhibo, et al.
Publicado: (2019)

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology
por: Samodelov, Sophia L., et al.
Publicado: (2020)

Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots
por: Samodelov, Sophia L, et al.
Publicado: (2019)

Renal Glycosuria as a Novel Early Sign of Colistin-Induced Kidney Damage in Mice
por: Samodelov, Sophia L., et al.
Publicado: (2019)

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage
por: Gai, Zhibo, et al.
Publicado: (2017)

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
por: Russmann, Stefan, et al.
Publicado: (2009)

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury
por: Gai, Zhibo, et al.
Publicado: (2023)

Lipid Accumulation and Chronic Kidney Disease
por: Gai, Zhibo, et al.
Publicado: (2019)

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity
por: Manley, Sharon, et al.
Publicado: (2014)

The Role of Mitochondria in Drug-Induced Kidney Injury
por: Gai, Zhibo, et al.
Publicado: (2020)

Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2)
por: Maane, Max, et al.
Publicado: (2023)

The Farnesoid X Receptor: Good for BAD
por: Keely, Stephen J., et al.
Publicado: (2016)

Farnesoid X receptor (FXR): Structures and ligands
por: Jiang, Longying, et al.
Publicado: (2021)

Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity
por: Jamshidi, Vahid, et al.
Publicado: (2021)

Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases
por: Wu, Jin-nan, et al.
Publicado: (2020)

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
por: Li, Hong, et al.
Publicado: (2019)

Drug-induced liver injury: the dawn of biomarkers?
por: Weiler, Stefan, et al.
Publicado: (2015)

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
por: Li, Guodong, et al.
Publicado: (2015)

Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota
por: Mori, Hideki, et al.
Publicado: (2022)

Farnesoid X receptor and bile acids regulate vitamin A storage
por: Saeed, Ali, et al.
Publicado: (2019)

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor
por: She, Jianglian, et al.
Publicado: (2022)

Role of farnesoid X receptor and bile acids in alcoholic liver disease
por: Manley, Sharon, et al.
Publicado: (2015)

Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists
por: Abenavoli, Ludovico, et al.
Publicado: (2020)

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
por: Wang, Xiaoxin X., et al.
Publicado: (2010)

Molecular tuning of farnesoid X receptor partial agonism
por: Merk, Daniel, et al.
Publicado: (2019)

Microbiota-induced obesity requires farnesoid X receptor
por: Parséus, Ava, et al.
Publicado: (2017)

Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
por: Zhang, Lu, et al.
Publicado: (2021)

Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury
por: Petrescu, Anca D., et al.
Publicado: (2021)

Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer
por: Girisa, Sosmitha, et al.
Publicado: (2021)

Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
por: Girisa, Sosmitha, et al.
Publicado: (2020)

Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet
por: Kundu, Payel, et al.
Publicado: (2022)

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets
por: Unsworth, Amanda J., et al.
Publicado: (2017)

Bacterial metabolites directly modulate farnesoid X receptor activity
por: Zhang, Xianqin, et al.
Publicado: (2015)

Allosteric modulation of the farnesoid X receptor by a small molecule
por: Gabler, Matthias, et al.
Publicado: (2018)

Identification of FDA-approved drugs targeting the Farnesoid X Receptor
por: van de Wiel, Sandra M. W., et al.
Publicado: (2019)

Farnesoid X Receptor Agonists as Therapeutic Target for Cardiometabolic Diseases
por: Li, Chao, et al.
Publicado: (2020)

The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease
por: Han, Chao, et al.
Publicado: (2022)

The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss
por: Zheng, Ting, et al.
Publicado: (2017)

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)
por: Kullak-Ublick, Gerd A., et al.
Publicado: (2014)

Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo
por: Hassan, Haider M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lehqa13u8438ha2e6npo410aho