Cargando…
Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients
Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695970/ https://www.ncbi.nlm.nih.gov/pubmed/36422258 http://dx.doi.org/10.3390/metabo12111118 |
_version_ | 1784838197752102912 |
---|---|
author | Janion, Karolina Strzelczyk, Joanna Katarzyna Walkiewicz, Katarzyna Weronika Biernacki, Krzysztof Copija, Angelika Szczepańska, Elżbieta Nowakowska-Zajdel, Ewa |
author_facet | Janion, Karolina Strzelczyk, Joanna Katarzyna Walkiewicz, Katarzyna Weronika Biernacki, Krzysztof Copija, Angelika Szczepańska, Elżbieta Nowakowska-Zajdel, Ewa |
author_sort | Janion, Karolina |
collection | PubMed |
description | Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected from both groups. Apart from that, anthropometric measurements were taken and other clinical data were analyzed. Serum malondialdehyde (MDA) level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were assayed. Subsequently, the relationship between the analyzed oxidative stress markers and selected clinical characteristics was investigated in both groups. The evaluation of oxidative stress marker values demonstrated that MDA and TAS levels were significantly higher in the control group than the CRC group (p < 0.001 and p = 0.019, respectively), while TOS levels were significantly higher in the CRC group than the control group (p = 0.005). Significantly lower OSI levels were found in the control group than in the CRC group (p < 0.001). Similar results can be observed when performing ROC analysis (receiver operating characteristic curve). Preliminary statistical analysis demonstrated that MDA levels in the study group depend on the location of the primary tumour (p = 0.035). Based on the post hoc Tukey test, a relationship was demonstrated between the MDA level and the left and right side of the colon (p = 0.040). The results may be evidence for a higher level of oxidative stress, including a compromised antioxidative defence system, in patients with CRC. |
format | Online Article Text |
id | pubmed-9695970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96959702022-11-26 Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients Janion, Karolina Strzelczyk, Joanna Katarzyna Walkiewicz, Katarzyna Weronika Biernacki, Krzysztof Copija, Angelika Szczepańska, Elżbieta Nowakowska-Zajdel, Ewa Metabolites Article Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) and 26 hospitalized patients (12 men and 14 women) in whom CRC was excluded (control group). During hospitalization, blood serum samples were collected from both groups. Apart from that, anthropometric measurements were taken and other clinical data were analyzed. Serum malondialdehyde (MDA) level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were assayed. Subsequently, the relationship between the analyzed oxidative stress markers and selected clinical characteristics was investigated in both groups. The evaluation of oxidative stress marker values demonstrated that MDA and TAS levels were significantly higher in the control group than the CRC group (p < 0.001 and p = 0.019, respectively), while TOS levels were significantly higher in the CRC group than the control group (p = 0.005). Significantly lower OSI levels were found in the control group than in the CRC group (p < 0.001). Similar results can be observed when performing ROC analysis (receiver operating characteristic curve). Preliminary statistical analysis demonstrated that MDA levels in the study group depend on the location of the primary tumour (p = 0.035). Based on the post hoc Tukey test, a relationship was demonstrated between the MDA level and the left and right side of the colon (p = 0.040). The results may be evidence for a higher level of oxidative stress, including a compromised antioxidative defence system, in patients with CRC. MDPI 2022-11-15 /pmc/articles/PMC9695970/ /pubmed/36422258 http://dx.doi.org/10.3390/metabo12111118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Janion, Karolina Strzelczyk, Joanna Katarzyna Walkiewicz, Katarzyna Weronika Biernacki, Krzysztof Copija, Angelika Szczepańska, Elżbieta Nowakowska-Zajdel, Ewa Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title_full | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title_fullStr | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title_full_unstemmed | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title_short | Evaluation of Malondialdehyde Level, Total Oxidant/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients |
title_sort | evaluation of malondialdehyde level, total oxidant/antioxidant status and oxidative stress index in colorectal cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695970/ https://www.ncbi.nlm.nih.gov/pubmed/36422258 http://dx.doi.org/10.3390/metabo12111118 |
work_keys_str_mv | AT janionkarolina evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT strzelczykjoannakatarzyna evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT walkiewiczkatarzynaweronika evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT biernackikrzysztof evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT copijaangelika evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT szczepanskaelzbieta evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients AT nowakowskazajdelewa evaluationofmalondialdehydeleveltotaloxidantantioxidantstatusandoxidativestressindexincolorectalcancerpatients |