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The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years

After initially having low levels of SARS-CoV-2 infections for much of the year, Bulgaria experienced a major epidemic surge at the end of 2020, which caused the highest recorded excess mortality in Europe, among the highest in the word (Excess Mortality Rate, or EMR ∼0.25%). Two more major waves fo...

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Detalles Bibliográficos
Autores principales: Rangachev, Antoni, Marinov, Georgi K., Mladenov, Mladen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696094/
https://www.ncbi.nlm.nih.gov/pubmed/36366409
http://dx.doi.org/10.3390/vaccines10111901
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author Rangachev, Antoni
Marinov, Georgi K.
Mladenov, Mladen
author_facet Rangachev, Antoni
Marinov, Georgi K.
Mladenov, Mladen
author_sort Rangachev, Antoni
collection PubMed
description After initially having low levels of SARS-CoV-2 infections for much of the year, Bulgaria experienced a major epidemic surge at the end of 2020, which caused the highest recorded excess mortality in Europe, among the highest in the word (Excess Mortality Rate, or EMR ∼0.25%). Two more major waves followed in 2021, followed by another one in early 2022. In this study, we analyze the temporal and spatial patterns of excess mortality at the national and local levels and across different demographic groups in Bulgaria and compare those to the European levels. Bulgaria has continued to exhibit the previous pattern of extremely high excess mortality, as measured both by crude mortality metrics (an EMR of ∼1.05%, up to the end of March 2022) and by standardized ones—Potential Years of Life Lost (PYLL) and Aged-Standardized Years of life lost Rate (ASYR). Unlike Western Europe, the bulk of excess mortality in Bulgaria, as well as in several other countries in Eastern Europe, occurred in the second year of the pandemic, likely related to the differences in the levels of vaccination coverage between these regions. We also observe even more extreme levels of excess mortality at the regional level and in some subpopulations (e.g., total EMR values for males ≥ 2% and EMR values for males aged 40–64 ≥ 1% in certain areas). We discuss these observations in light of the estimates of infection fatality rate (IFR) and eventual population fatality rate (PFR) made early in the course of the pandemic.
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spelling pubmed-96960942022-11-26 The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years Rangachev, Antoni Marinov, Georgi K. Mladenov, Mladen Vaccines (Basel) Article After initially having low levels of SARS-CoV-2 infections for much of the year, Bulgaria experienced a major epidemic surge at the end of 2020, which caused the highest recorded excess mortality in Europe, among the highest in the word (Excess Mortality Rate, or EMR ∼0.25%). Two more major waves followed in 2021, followed by another one in early 2022. In this study, we analyze the temporal and spatial patterns of excess mortality at the national and local levels and across different demographic groups in Bulgaria and compare those to the European levels. Bulgaria has continued to exhibit the previous pattern of extremely high excess mortality, as measured both by crude mortality metrics (an EMR of ∼1.05%, up to the end of March 2022) and by standardized ones—Potential Years of Life Lost (PYLL) and Aged-Standardized Years of life lost Rate (ASYR). Unlike Western Europe, the bulk of excess mortality in Bulgaria, as well as in several other countries in Eastern Europe, occurred in the second year of the pandemic, likely related to the differences in the levels of vaccination coverage between these regions. We also observe even more extreme levels of excess mortality at the regional level and in some subpopulations (e.g., total EMR values for males ≥ 2% and EMR values for males aged 40–64 ≥ 1% in certain areas). We discuss these observations in light of the estimates of infection fatality rate (IFR) and eventual population fatality rate (PFR) made early in the course of the pandemic. MDPI 2022-11-10 /pmc/articles/PMC9696094/ /pubmed/36366409 http://dx.doi.org/10.3390/vaccines10111901 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rangachev, Antoni
Marinov, Georgi K.
Mladenov, Mladen
The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title_full The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title_fullStr The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title_full_unstemmed The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title_short The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years
title_sort impact and progression of the covid-19 pandemic in bulgaria in its first two years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696094/
https://www.ncbi.nlm.nih.gov/pubmed/36366409
http://dx.doi.org/10.3390/vaccines10111901
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