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The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy

The rising incidence and severity of malignant tumors threaten human life and health, and the current lagged diagnosis and single treatment in clinical practice are inadequate for tumor management. Gold nanoclusters (AuNCs) are nanomaterials with small dimensions (≤3 nm) and few atoms exhibiting uni...

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Autores principales: Liu, Sisi, Wang, Junyao, Song, Yuxin, He, Shuya, Tan, Huaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696200/
https://www.ncbi.nlm.nih.gov/pubmed/36432642
http://dx.doi.org/10.3390/pharmaceutics14112451
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author Liu, Sisi
Wang, Junyao
Song, Yuxin
He, Shuya
Tan, Huaxin
author_facet Liu, Sisi
Wang, Junyao
Song, Yuxin
He, Shuya
Tan, Huaxin
author_sort Liu, Sisi
collection PubMed
description The rising incidence and severity of malignant tumors threaten human life and health, and the current lagged diagnosis and single treatment in clinical practice are inadequate for tumor management. Gold nanoclusters (AuNCs) are nanomaterials with small dimensions (≤3 nm) and few atoms exhibiting unique optoelectronic and physicochemical characteristics, such as fluorescence, photothermal effects, radiosensitization, and biocompatibility. Here, the three primary functions that AuNCs play in practical applications, imaging agents, drug transporters, and therapeutic nanosystems, are characterized. Additionally, the promise and remaining limitations of AuNCs for tumor theranostic and combination therapy are discussed. Finally, it is anticipated that the information presented herein will serve as a supply for researchers in this area, leading to new discoveries and ultimately a more widespread use of AuNCs in pharmaceuticals.
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spelling pubmed-96962002022-11-26 The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy Liu, Sisi Wang, Junyao Song, Yuxin He, Shuya Tan, Huaxin Pharmaceutics Review The rising incidence and severity of malignant tumors threaten human life and health, and the current lagged diagnosis and single treatment in clinical practice are inadequate for tumor management. Gold nanoclusters (AuNCs) are nanomaterials with small dimensions (≤3 nm) and few atoms exhibiting unique optoelectronic and physicochemical characteristics, such as fluorescence, photothermal effects, radiosensitization, and biocompatibility. Here, the three primary functions that AuNCs play in practical applications, imaging agents, drug transporters, and therapeutic nanosystems, are characterized. Additionally, the promise and remaining limitations of AuNCs for tumor theranostic and combination therapy are discussed. Finally, it is anticipated that the information presented herein will serve as a supply for researchers in this area, leading to new discoveries and ultimately a more widespread use of AuNCs in pharmaceuticals. MDPI 2022-11-14 /pmc/articles/PMC9696200/ /pubmed/36432642 http://dx.doi.org/10.3390/pharmaceutics14112451 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Sisi
Wang, Junyao
Song, Yuxin
He, Shuya
Tan, Huaxin
The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title_full The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title_fullStr The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title_full_unstemmed The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title_short The Recent Development of Multifunctional Gold Nanoclusters in Tumor Theranostic and Combination Therapy
title_sort recent development of multifunctional gold nanoclusters in tumor theranostic and combination therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696200/
https://www.ncbi.nlm.nih.gov/pubmed/36432642
http://dx.doi.org/10.3390/pharmaceutics14112451
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