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J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study

We aim to examine the prospective association between the intake of dietary tomatoes and the risk of new-onset hypertension and its modifiable factors in general adults. A total of 11,460 adults without hypertension from the China Health and Nutrition Survey (CHNS) were enrolled, with follow-up begi...

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Autores principales: Zhao, Dan, Tian, Zezhong, Liang, Ying, Chen, Hong, Fan, Zhiying, Liu, Zhihao, Dai, Suming, Liu, Meitong, Kuang, Huiying, Yang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696212/
https://www.ncbi.nlm.nih.gov/pubmed/36432500
http://dx.doi.org/10.3390/nu14224813
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author Zhao, Dan
Tian, Zezhong
Liang, Ying
Chen, Hong
Fan, Zhiying
Liu, Zhihao
Dai, Suming
Liu, Meitong
Kuang, Huiying
Yang, Yan
author_facet Zhao, Dan
Tian, Zezhong
Liang, Ying
Chen, Hong
Fan, Zhiying
Liu, Zhihao
Dai, Suming
Liu, Meitong
Kuang, Huiying
Yang, Yan
author_sort Zhao, Dan
collection PubMed
description We aim to examine the prospective association between the intake of dietary tomatoes and the risk of new-onset hypertension and its modifiable factors in general adults. A total of 11,460 adults without hypertension from the China Health and Nutrition Survey (CHNS) were enrolled, with follow-up beginning in 1997 and ending in 2015. Dietary tomato intake was measured by three consecutive 24-h dietary recalls combined with a household food inventory. The study outcome was new-onset hypertension, defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by physicians or under anti-hypertensive treatment during the follow-up. Finally, 4015 subjects developed new-onset hypertension during 92,335.5 person-years of follow-up. After multivariate adjustment for dietary and non-dietary risk factors, hazard ratios for increased consumption of dietary tomatoes were 0.42 (95% confidence interval, 0.37–0.47), 0.51 (0.46–0.57), and 0.82 (0.74–0.92) compared with non-consumers. Overall, cubic spline regression suggested a novel J-shaped association between dietary tomato intake and new-onset hypertension, with the lowest risk observed at approximately 10 to 13 g/day (p < 0.001 for curvature). Moreover, the association between dietary tomato intake and risk of new-onset hypertension was stronger in females or individuals who refrained from smoking or drinking (p = 0.024, p = 0.043, and p = 0.044 for interaction, respectively).
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spelling pubmed-96962122022-11-26 J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study Zhao, Dan Tian, Zezhong Liang, Ying Chen, Hong Fan, Zhiying Liu, Zhihao Dai, Suming Liu, Meitong Kuang, Huiying Yang, Yan Nutrients Article We aim to examine the prospective association between the intake of dietary tomatoes and the risk of new-onset hypertension and its modifiable factors in general adults. A total of 11,460 adults without hypertension from the China Health and Nutrition Survey (CHNS) were enrolled, with follow-up beginning in 1997 and ending in 2015. Dietary tomato intake was measured by three consecutive 24-h dietary recalls combined with a household food inventory. The study outcome was new-onset hypertension, defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by physicians or under anti-hypertensive treatment during the follow-up. Finally, 4015 subjects developed new-onset hypertension during 92,335.5 person-years of follow-up. After multivariate adjustment for dietary and non-dietary risk factors, hazard ratios for increased consumption of dietary tomatoes were 0.42 (95% confidence interval, 0.37–0.47), 0.51 (0.46–0.57), and 0.82 (0.74–0.92) compared with non-consumers. Overall, cubic spline regression suggested a novel J-shaped association between dietary tomato intake and new-onset hypertension, with the lowest risk observed at approximately 10 to 13 g/day (p < 0.001 for curvature). Moreover, the association between dietary tomato intake and risk of new-onset hypertension was stronger in females or individuals who refrained from smoking or drinking (p = 0.024, p = 0.043, and p = 0.044 for interaction, respectively). MDPI 2022-11-14 /pmc/articles/PMC9696212/ /pubmed/36432500 http://dx.doi.org/10.3390/nu14224813 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Dan
Tian, Zezhong
Liang, Ying
Chen, Hong
Fan, Zhiying
Liu, Zhihao
Dai, Suming
Liu, Meitong
Kuang, Huiying
Yang, Yan
J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title_full J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title_fullStr J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title_full_unstemmed J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title_short J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study
title_sort j-shaped association of tomato intake with new-onset hypertension in general adults: a nationwide prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696212/
https://www.ncbi.nlm.nih.gov/pubmed/36432500
http://dx.doi.org/10.3390/nu14224813
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