Cargando…

Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021

African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Ki-Hyun, Hong, Seong-Keun, Jang, Min-Kyung, Ryu, Ji-Hyoung, Kim, Hyun-Jeong, Lee, Yu-Ran, Roh, In-Soon, Sohn, Hyun-Joo, Kang, Hae-Eun, Park, Jee-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696264/
https://www.ncbi.nlm.nih.gov/pubmed/36423121
http://dx.doi.org/10.3390/v14112512
_version_ 1784838267043053568
author Cho, Ki-Hyun
Hong, Seong-Keun
Jang, Min-Kyung
Ryu, Ji-Hyoung
Kim, Hyun-Jeong
Lee, Yu-Ran
Roh, In-Soon
Sohn, Hyun-Joo
Kang, Hae-Eun
Park, Jee-Yong
author_facet Cho, Ki-Hyun
Hong, Seong-Keun
Jang, Min-Kyung
Ryu, Ji-Hyoung
Kim, Hyun-Jeong
Lee, Yu-Ran
Roh, In-Soon
Sohn, Hyun-Joo
Kang, Hae-Eun
Park, Jee-Yong
author_sort Cho, Ki-Hyun
collection PubMed
description African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in domestic pigs, concerns were raised about the possible changes in virulence occurring among African swine fever viruses (ASFV) circulating in South Korea. In this study, four Korean ASFV strains isolated from domestic pig farms at different time points between 2019 and 2021 were chosen, and used to experimentally infect domestic pigs by intramuscular inoculation to compare their virulence. All challenged pigs died at 4–9 days post-inoculation, with many showing clinical symptoms of fever, depression, loss of appetite, and recumbency. Gross lesions observed at necropsy included enlargement and hemorrhage of the lymph nodes and hydropericardium. The study showed that all four Korean ASFV isolates caused acute forms of illness, which supports the view that virulence among the circulating ASFV isolates in South Korea remained unchanged and highly virulent during this period.
format Online
Article
Text
id pubmed-9696264
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96962642022-11-26 Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 Cho, Ki-Hyun Hong, Seong-Keun Jang, Min-Kyung Ryu, Ji-Hyoung Kim, Hyun-Jeong Lee, Yu-Ran Roh, In-Soon Sohn, Hyun-Joo Kang, Hae-Eun Park, Jee-Yong Viruses Article African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in domestic pigs, concerns were raised about the possible changes in virulence occurring among African swine fever viruses (ASFV) circulating in South Korea. In this study, four Korean ASFV strains isolated from domestic pig farms at different time points between 2019 and 2021 were chosen, and used to experimentally infect domestic pigs by intramuscular inoculation to compare their virulence. All challenged pigs died at 4–9 days post-inoculation, with many showing clinical symptoms of fever, depression, loss of appetite, and recumbency. Gross lesions observed at necropsy included enlargement and hemorrhage of the lymph nodes and hydropericardium. The study showed that all four Korean ASFV isolates caused acute forms of illness, which supports the view that virulence among the circulating ASFV isolates in South Korea remained unchanged and highly virulent during this period. MDPI 2022-11-13 /pmc/articles/PMC9696264/ /pubmed/36423121 http://dx.doi.org/10.3390/v14112512 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cho, Ki-Hyun
Hong, Seong-Keun
Jang, Min-Kyung
Ryu, Ji-Hyoung
Kim, Hyun-Jeong
Lee, Yu-Ran
Roh, In-Soon
Sohn, Hyun-Joo
Kang, Hae-Eun
Park, Jee-Yong
Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title_full Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title_fullStr Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title_full_unstemmed Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title_short Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
title_sort comparison of the virulence of korean african swine fever isolates from pig farms during 2019–2021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696264/
https://www.ncbi.nlm.nih.gov/pubmed/36423121
http://dx.doi.org/10.3390/v14112512
work_keys_str_mv AT chokihyun comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT hongseongkeun comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT jangminkyung comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT ryujihyoung comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT kimhyunjeong comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT leeyuran comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT rohinsoon comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT sohnhyunjoo comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT kanghaeeun comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021
AT parkjeeyong comparisonofthevirulenceofkoreanafricanswinefeverisolatesfrompigfarmsduring20192021