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Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021
African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696264/ https://www.ncbi.nlm.nih.gov/pubmed/36423121 http://dx.doi.org/10.3390/v14112512 |
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author | Cho, Ki-Hyun Hong, Seong-Keun Jang, Min-Kyung Ryu, Ji-Hyoung Kim, Hyun-Jeong Lee, Yu-Ran Roh, In-Soon Sohn, Hyun-Joo Kang, Hae-Eun Park, Jee-Yong |
author_facet | Cho, Ki-Hyun Hong, Seong-Keun Jang, Min-Kyung Ryu, Ji-Hyoung Kim, Hyun-Jeong Lee, Yu-Ran Roh, In-Soon Sohn, Hyun-Joo Kang, Hae-Eun Park, Jee-Yong |
author_sort | Cho, Ki-Hyun |
collection | PubMed |
description | African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in domestic pigs, concerns were raised about the possible changes in virulence occurring among African swine fever viruses (ASFV) circulating in South Korea. In this study, four Korean ASFV strains isolated from domestic pig farms at different time points between 2019 and 2021 were chosen, and used to experimentally infect domestic pigs by intramuscular inoculation to compare their virulence. All challenged pigs died at 4–9 days post-inoculation, with many showing clinical symptoms of fever, depression, loss of appetite, and recumbency. Gross lesions observed at necropsy included enlargement and hemorrhage of the lymph nodes and hydropericardium. The study showed that all four Korean ASFV isolates caused acute forms of illness, which supports the view that virulence among the circulating ASFV isolates in South Korea remained unchanged and highly virulent during this period. |
format | Online Article Text |
id | pubmed-9696264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96962642022-11-26 Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 Cho, Ki-Hyun Hong, Seong-Keun Jang, Min-Kyung Ryu, Ji-Hyoung Kim, Hyun-Jeong Lee, Yu-Ran Roh, In-Soon Sohn, Hyun-Joo Kang, Hae-Eun Park, Jee-Yong Viruses Article African swine fever (ASF) was first reported in South Korea in September 2019, and as of 31 December 2021, a total of 21 cases in domestic pig farms and 1875 ASFV-infected wild boars have been confirmed in the country. With the continued circulation of ASF in wild boars, and subsequent outbreaks in domestic pigs, concerns were raised about the possible changes in virulence occurring among African swine fever viruses (ASFV) circulating in South Korea. In this study, four Korean ASFV strains isolated from domestic pig farms at different time points between 2019 and 2021 were chosen, and used to experimentally infect domestic pigs by intramuscular inoculation to compare their virulence. All challenged pigs died at 4–9 days post-inoculation, with many showing clinical symptoms of fever, depression, loss of appetite, and recumbency. Gross lesions observed at necropsy included enlargement and hemorrhage of the lymph nodes and hydropericardium. The study showed that all four Korean ASFV isolates caused acute forms of illness, which supports the view that virulence among the circulating ASFV isolates in South Korea remained unchanged and highly virulent during this period. MDPI 2022-11-13 /pmc/articles/PMC9696264/ /pubmed/36423121 http://dx.doi.org/10.3390/v14112512 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cho, Ki-Hyun Hong, Seong-Keun Jang, Min-Kyung Ryu, Ji-Hyoung Kim, Hyun-Jeong Lee, Yu-Ran Roh, In-Soon Sohn, Hyun-Joo Kang, Hae-Eun Park, Jee-Yong Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title | Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title_full | Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title_fullStr | Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title_full_unstemmed | Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title_short | Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019–2021 |
title_sort | comparison of the virulence of korean african swine fever isolates from pig farms during 2019–2021 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696264/ https://www.ncbi.nlm.nih.gov/pubmed/36423121 http://dx.doi.org/10.3390/v14112512 |
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