Pulmonary Delivery of Favipiravir in Rats Reaches High Local Concentrations without Causing Oxidative Lung Injury or Systemic Side Effects

Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the pulmonary route could provide a high drug concentration, and a safer application w...

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Detalles Bibliográficos
Autores principales: Akbal-Dagistan, Ozlem, Sevim, Mustafa, Sen, Leyla Semiha, Basarir, Nur Sena, Culha, Meltem, Erturk, Aybige, Fael, Hanan, Kaptan, Engin, Sancar, Serap, Mulazimoglu Durmusoglu, Lutfiye, Yegen, Berrak C., Yildiz-Pekoz, Ayca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696372/
https://www.ncbi.nlm.nih.gov/pubmed/36365193
http://dx.doi.org/10.3390/pharmaceutics14112375

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