Cargando…

Pharmacological Validation of Long-Term Treatment with Antiretroviral Drugs in a Model of SIV-Infected Non-Human Primates

The development of animal models undergoing long-term antiretroviral treatment (ART) makes it possible to understand a number of immunological, virological, and pharmacological issues, key factors in the management of HIV infection. We aimed to pharmacologically validate a non-human primate (NHP) mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gelé, Thibaut, Gouget, Hélène, Dereuddre-Bosquet, Nathalie, Furlan, Valérie, Le Grand, Roger, Lambotte, Olivier, Desjardins, Delphine, Barrail-Tran, Aurélie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696548/ https://www.ncbi.nlm.nih.gov/pubmed/36365101 http://dx.doi.org/10.3390/pharmaceutics14112282

Ejemplares similares

Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques
por: Mausoléo, Aude, et al.
Publicado: (2022)

Cynomolgus macaque IL37 polymorphism and control of SIV infection
por: Shiina, Takashi, et al.
Publicado: (2019)

Identification of CX3CR1(+) mononuclear phagocyte subsets involved in HIV-1 and SIV colorectal transmission
por: Cavarelli, Mariangela, et al.
Publicado: (2022)

Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence
por: Bourgeois, Christine, et al.
Publicado: (2019)

Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates
por: Le Grand, Roger, et al.
Publicado: (2016)

Tissue viral dynamics in SIV infected macaques with highly active antiretroviral therapy (HAART)
por: Bourry, Olivier, et al.
Publicado: (2009)

Semen CD4(+) T Cells and Macrophages Are Productively Infected at All Stages of SIV infection in Macaques
por: Bernard-Stoecklin, Sibylle, et al.
Publicado: (2013)

Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants
por: Cavarelli, Mariangela, et al.
Publicado: (2021)

Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function
por: Lemaitre, Julien, et al.
Publicado: (2022)

Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion
por: Bourry, Olivier, et al.
Publicado: (2010)

Innate and Adaptive Anti-SIV Responses in Macaque Semen: Implications for Infectivity and Risk of Transmission
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2020)

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques
por: Bruel, Timothée, et al.
Publicado: (2014)

Broadly neutralizing antibodies potently inhibit cell-to-cell transmission of semen leukocyte-derived SHIV162P3
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2020)

Antiretroviral Treatment Start-Time during Primary SIV(mac) Infection in Macaques Exerts a Different Impact on Early Viral Replication and Dissemination
por: Sellier, Pierre, et al.
Publicado: (2010)

Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model
por: de Manuel, Marc, et al.
Publicado: (2018)

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection
por: Damouche, Abderaouf, et al.
Publicado: (2015)

Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2023)

Dolutegravir Cerebrospinal Fluid Diffusion in HIV-1–Infected Patients with Central Nervous System Impairment
por: Gelé, Thibaut, et al.
Publicado: (2019)

Loss and regain of SIV control upon CD8+ cell depletion in vivo in SIV-controller macaques is not associated with efficient SIV specific CD8+ T-cells
por: Hamimi, C, et al.
Publicado: (2012)

SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction
por: Gorwood, Jennifer, et al.
Publicado: (2020)

A Temperature-Monitoring Vaginal Ring for Measuring Adherence
por: Boyd, Peter, et al.
Publicado: (2015)

Correction: Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection
por: Echebli, Nadia, et al.
Publicado: (2018)

Distinct Features of Germinal Center Reactions in Macaques Infected by SIV or Vaccinated with a T-Dependent Model Antigen
por: Trovato, Maria, et al.
Publicado: (2021)

Overcoming immunogenicity issues of HIV p24 antigen by the use of innovative nanostructured lipid carriers as delivery systems: evidences in mice and non-human primates
por: Bayon, Emilie, et al.
Publicado: (2018)

Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection
por: Echebli, Nadia, et al.
Publicado: (2018)

Impact of BAFF Blockade on Inflammation, Germinal Center Reaction and Effector B-Cells During Acute SIV Infection
por: Borhis, Gwenoline, et al.
Publicado: (2020)

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections
por: Jochems, Simon P., et al.
Publicado: (2020)

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model
por: Lorenzen, Emma, et al.
Publicado: (2022)

Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes
por: Ngono Ayissi, Kenza, et al.
Publicado: (2022)

Mapping of SIVmac T-cell epitopes in cynomolgus macaques immunized with auxo-GTU-MultiSIV DNA by the intradermal route followed by electroporation
por: Corneau, A, et al.
Publicado: (2012)

Impact of Short-Term HAART Initiated during the Chronic Stage or Shortly Post-Exposure on SIV Infection of Male Genital Organs
por: Moreau, Marina, et al.
Publicado: (2012)

Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates
por: Marlin, Romain, et al.
Publicado: (2022)

Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection
por: Alexandre, Marie, et al.
Publicado: (2022)

The Frequencies of Immunosuppressive Cells in Adipose Tissue Differ in Human, Non-human Primate, and Mouse Models
por: Laparra, Ariane, et al.
Publicado: (2019)

Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
por: Marc, Aurélien, et al.
Publicado: (2023)

Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque
por: Olivo, Anaëlle, et al.
Publicado: (2022)

Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model
por: Hérate, Cécile, et al.
Publicado: (2023)

Targeting HIV Gag p24 to DICR on dendritic cells induces T cell and potent and long-lasting antibody responses in non-human primates
por: Flamar, A, et al.
Publicado: (2012)

Non-neutralizing IgG anti-PID antibodies decreased viral load following high dose vaginal challenge of non-human primates
por: Moog, C, et al.
Publicado: (2012)

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge
por: Ariën, Kevin K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qvjftj6l7i6g4ad0g083t48a3m