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Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance

Medical personnel are a group of people that often encounter infectious agents, leading to greater risk of contracting infectious diseases. Specific prevention of diseases in this group is a priority. The epidemiological effectiveness of COVID-19 prevention in the group of medical workers due to the...

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Autores principales: Sukhikh, Gennady T., Priputnevich, Tatiana V., Ogarkova, Darya A., Pochtovyi, Andrei A., Kustova, Daria D., Zlobin, Vladimir I., Logunov, Denis Y., Gushchin, Vladimir A., Gintsburg, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696561/
https://www.ncbi.nlm.nih.gov/pubmed/36366311
http://dx.doi.org/10.3390/vaccines10111804
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author Sukhikh, Gennady T.
Priputnevich, Tatiana V.
Ogarkova, Darya A.
Pochtovyi, Andrei A.
Kustova, Daria D.
Zlobin, Vladimir I.
Logunov, Denis Y.
Gushchin, Vladimir A.
Gintsburg, Alexander L.
author_facet Sukhikh, Gennady T.
Priputnevich, Tatiana V.
Ogarkova, Darya A.
Pochtovyi, Andrei A.
Kustova, Daria D.
Zlobin, Vladimir I.
Logunov, Denis Y.
Gushchin, Vladimir A.
Gintsburg, Alexander L.
author_sort Sukhikh, Gennady T.
collection PubMed
description Medical personnel are a group of people that often encounter infectious agents, leading to greater risk of contracting infectious diseases. Specific prevention of diseases in this group is a priority. The epidemiological effectiveness of COVID-19 prevention in the group of medical workers due to the emergence of new variants of concern of the SARS-CoV-2 virus has not been studied in sufficient depth. We conducted a study of the effectiveness of vaccine use to protect medical workers at a large medical center for obstetrics and gynecology in Moscow. Sputnik V and Sputnik Light were the main vaccines used for the prevention of COVID-19. The vaccines are based on a variant of the S-protein of the SARS-CoV-2 virus, with adenovirus serotypes 5 and 26 as the vector for delivery. Vaccination of employees occurred during the period in which the Delta variant was spreading. The overall epidemiological effectiveness was 81.7% (73.1–87.6%) during the period in which the Delta variant was dominant. During the period from the beginning of vaccination (26 November 2020) until 8 February 2022, the overall effectiveness was 89.1% (86.9–91.0%). As expected, the highest effectiveness during this period was obtained in the group that received the third and fourth doses—96.5% (75.0–99.5%). The severity of COVID-19 in the vaccinated group was significantly lower than in the unvaccinated group.
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spelling pubmed-96965612022-11-26 Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance Sukhikh, Gennady T. Priputnevich, Tatiana V. Ogarkova, Darya A. Pochtovyi, Andrei A. Kustova, Daria D. Zlobin, Vladimir I. Logunov, Denis Y. Gushchin, Vladimir A. Gintsburg, Alexander L. Vaccines (Basel) Article Medical personnel are a group of people that often encounter infectious agents, leading to greater risk of contracting infectious diseases. Specific prevention of diseases in this group is a priority. The epidemiological effectiveness of COVID-19 prevention in the group of medical workers due to the emergence of new variants of concern of the SARS-CoV-2 virus has not been studied in sufficient depth. We conducted a study of the effectiveness of vaccine use to protect medical workers at a large medical center for obstetrics and gynecology in Moscow. Sputnik V and Sputnik Light were the main vaccines used for the prevention of COVID-19. The vaccines are based on a variant of the S-protein of the SARS-CoV-2 virus, with adenovirus serotypes 5 and 26 as the vector for delivery. Vaccination of employees occurred during the period in which the Delta variant was spreading. The overall epidemiological effectiveness was 81.7% (73.1–87.6%) during the period in which the Delta variant was dominant. During the period from the beginning of vaccination (26 November 2020) until 8 February 2022, the overall effectiveness was 89.1% (86.9–91.0%). As expected, the highest effectiveness during this period was obtained in the group that received the third and fourth doses—96.5% (75.0–99.5%). The severity of COVID-19 in the vaccinated group was significantly lower than in the unvaccinated group. MDPI 2022-10-26 /pmc/articles/PMC9696561/ /pubmed/36366311 http://dx.doi.org/10.3390/vaccines10111804 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sukhikh, Gennady T.
Priputnevich, Tatiana V.
Ogarkova, Darya A.
Pochtovyi, Andrei A.
Kustova, Daria D.
Zlobin, Vladimir I.
Logunov, Denis Y.
Gushchin, Vladimir A.
Gintsburg, Alexander L.
Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title_full Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title_fullStr Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title_full_unstemmed Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title_short Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
title_sort sputnik light and sputnik v vaccination is effective at protecting medical personnel from covid-19 during the period of delta variant dominance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696561/
https://www.ncbi.nlm.nih.gov/pubmed/36366311
http://dx.doi.org/10.3390/vaccines10111804
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