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Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence

Previous studies have suggested a “cholesterol-lowering effect” of preclinical pancreatic cancer, suggesting lower total cholesterol as a potential diagnostic marker. Leveraging repeated measurements of total cholesterol, this study aims to examine the temporal association of total cholesterol and p...

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Autores principales: Wang, Qiao-Li, Khil, Jaewon, Hong, SungEun, Lee, Dong Hoon, Ha, Kyoung Hwa, Keum, NaNa, Kim, Hyeon Chang, Giovannucci, Edward L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696583/
https://www.ncbi.nlm.nih.gov/pubmed/36432624
http://dx.doi.org/10.3390/nu14224938
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author Wang, Qiao-Li
Khil, Jaewon
Hong, SungEun
Lee, Dong Hoon
Ha, Kyoung Hwa
Keum, NaNa
Kim, Hyeon Chang
Giovannucci, Edward L.
author_facet Wang, Qiao-Li
Khil, Jaewon
Hong, SungEun
Lee, Dong Hoon
Ha, Kyoung Hwa
Keum, NaNa
Kim, Hyeon Chang
Giovannucci, Edward L.
author_sort Wang, Qiao-Li
collection PubMed
description Previous studies have suggested a “cholesterol-lowering effect” of preclinical pancreatic cancer, suggesting lower total cholesterol as a potential diagnostic marker. Leveraging repeated measurements of total cholesterol, this study aims to examine the temporal association of total cholesterol and pancreatic cancer incidence. We conducted a nested case-control study based on a Korean National Health Insurance Service–Health Screening Cohort, including 215 pancreatic cancer cases and 645 controls matched on age and sex. Conditional logistic regression was applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the associations of pancreatic cancer incidence with total cholesterol levels across different time windows over 11 years before pancreatic cancer diagnosis (recent, mid, distant). We found that, compared to participants with total cholesterol < 200 mg/dL in the recent 3 years prior to diagnosis, those having total cholesterol ≥ 240 mg/dL showed a significantly lower pancreatic cancer incidence (OR = 0.50 (0.27–0.93)). No significant association was found in relation to total cholesterol measured in the mid and distant past. When changes in total cholesterol over the three time periods were analyzed, compared with those with total cholesterol levels consistently below 240 mg/dL over the entire period, the OR of pancreatic cancer was 0.45 (0.20–1.03) for participants with recent-onset hypercholesterolemia, 1.89 (0.95–3.75) for recent-resolved hypercholesterolemia, and 0.71 (0.30–1.66) for consistent hypercholesterolemia. In conclusion, while high total cholesterol in the recent past may indicate a lower pancreatic cancer incidence, a recent decrease in total cholesterol may suggest an elevated incidence of pancreatic cancer.
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spelling pubmed-96965832022-11-26 Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence Wang, Qiao-Li Khil, Jaewon Hong, SungEun Lee, Dong Hoon Ha, Kyoung Hwa Keum, NaNa Kim, Hyeon Chang Giovannucci, Edward L. Nutrients Article Previous studies have suggested a “cholesterol-lowering effect” of preclinical pancreatic cancer, suggesting lower total cholesterol as a potential diagnostic marker. Leveraging repeated measurements of total cholesterol, this study aims to examine the temporal association of total cholesterol and pancreatic cancer incidence. We conducted a nested case-control study based on a Korean National Health Insurance Service–Health Screening Cohort, including 215 pancreatic cancer cases and 645 controls matched on age and sex. Conditional logistic regression was applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the associations of pancreatic cancer incidence with total cholesterol levels across different time windows over 11 years before pancreatic cancer diagnosis (recent, mid, distant). We found that, compared to participants with total cholesterol < 200 mg/dL in the recent 3 years prior to diagnosis, those having total cholesterol ≥ 240 mg/dL showed a significantly lower pancreatic cancer incidence (OR = 0.50 (0.27–0.93)). No significant association was found in relation to total cholesterol measured in the mid and distant past. When changes in total cholesterol over the three time periods were analyzed, compared with those with total cholesterol levels consistently below 240 mg/dL over the entire period, the OR of pancreatic cancer was 0.45 (0.20–1.03) for participants with recent-onset hypercholesterolemia, 1.89 (0.95–3.75) for recent-resolved hypercholesterolemia, and 0.71 (0.30–1.66) for consistent hypercholesterolemia. In conclusion, while high total cholesterol in the recent past may indicate a lower pancreatic cancer incidence, a recent decrease in total cholesterol may suggest an elevated incidence of pancreatic cancer. MDPI 2022-11-21 /pmc/articles/PMC9696583/ /pubmed/36432624 http://dx.doi.org/10.3390/nu14224938 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Qiao-Li
Khil, Jaewon
Hong, SungEun
Lee, Dong Hoon
Ha, Kyoung Hwa
Keum, NaNa
Kim, Hyeon Chang
Giovannucci, Edward L.
Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title_full Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title_fullStr Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title_full_unstemmed Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title_short Temporal Association of Total Serum Cholesterol and Pancreatic Cancer Incidence
title_sort temporal association of total serum cholesterol and pancreatic cancer incidence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696583/
https://www.ncbi.nlm.nih.gov/pubmed/36432624
http://dx.doi.org/10.3390/nu14224938
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