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A Review of Potential Therapeutic Strategies for COVID-19

Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat with increasing death tolls worldwide. SARS-CoV-2 belongs to lineage B β-CoV, a subgroup of Sarbecovirus. These enveloped, large,...

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Autores principales: Meng, Jiajia, Li, Ruijiao, Zhang, Zhiqi, Wang, Jie, Huang, Qingwen, Nie, Dongxia, Fan, Kai, Guo, Wenbo, Zhao, Zhihui, Han, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696587/
https://www.ncbi.nlm.nih.gov/pubmed/36366444
http://dx.doi.org/10.3390/v14112346
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author Meng, Jiajia
Li, Ruijiao
Zhang, Zhiqi
Wang, Jie
Huang, Qingwen
Nie, Dongxia
Fan, Kai
Guo, Wenbo
Zhao, Zhihui
Han, Zheng
author_facet Meng, Jiajia
Li, Ruijiao
Zhang, Zhiqi
Wang, Jie
Huang, Qingwen
Nie, Dongxia
Fan, Kai
Guo, Wenbo
Zhao, Zhihui
Han, Zheng
author_sort Meng, Jiajia
collection PubMed
description Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat with increasing death tolls worldwide. SARS-CoV-2 belongs to lineage B β-CoV, a subgroup of Sarbecovirus. These enveloped, large, positive-sense single-stranded RNA viruses are easily spread among individuals, mainly via the respiratory system and droplets. Although the disease has been gradually controlled in many countries, once social restrictions are relaxed the virus may rebound, leading to a more severe and uncontrollable situation again, as occurred in Shanghai, China, in 2022. The current global health threat calls for the urgent development of effective therapeutic options for the treatment and prevention of SARS-CoV-2 infection. This systematic overview of possible SARS-CoV-2 therapeutic strategies from 2019 to 2022 indicates three potential targets: virus entry, virus replication, and the immune system. The information provided in this review will aid the development of more potent and specific antiviral compounds.
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spelling pubmed-96965872022-11-26 A Review of Potential Therapeutic Strategies for COVID-19 Meng, Jiajia Li, Ruijiao Zhang, Zhiqi Wang, Jie Huang, Qingwen Nie, Dongxia Fan, Kai Guo, Wenbo Zhao, Zhihui Han, Zheng Viruses Review Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat with increasing death tolls worldwide. SARS-CoV-2 belongs to lineage B β-CoV, a subgroup of Sarbecovirus. These enveloped, large, positive-sense single-stranded RNA viruses are easily spread among individuals, mainly via the respiratory system and droplets. Although the disease has been gradually controlled in many countries, once social restrictions are relaxed the virus may rebound, leading to a more severe and uncontrollable situation again, as occurred in Shanghai, China, in 2022. The current global health threat calls for the urgent development of effective therapeutic options for the treatment and prevention of SARS-CoV-2 infection. This systematic overview of possible SARS-CoV-2 therapeutic strategies from 2019 to 2022 indicates three potential targets: virus entry, virus replication, and the immune system. The information provided in this review will aid the development of more potent and specific antiviral compounds. MDPI 2022-10-25 /pmc/articles/PMC9696587/ /pubmed/36366444 http://dx.doi.org/10.3390/v14112346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meng, Jiajia
Li, Ruijiao
Zhang, Zhiqi
Wang, Jie
Huang, Qingwen
Nie, Dongxia
Fan, Kai
Guo, Wenbo
Zhao, Zhihui
Han, Zheng
A Review of Potential Therapeutic Strategies for COVID-19
title A Review of Potential Therapeutic Strategies for COVID-19
title_full A Review of Potential Therapeutic Strategies for COVID-19
title_fullStr A Review of Potential Therapeutic Strategies for COVID-19
title_full_unstemmed A Review of Potential Therapeutic Strategies for COVID-19
title_short A Review of Potential Therapeutic Strategies for COVID-19
title_sort review of potential therapeutic strategies for covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696587/
https://www.ncbi.nlm.nih.gov/pubmed/36366444
http://dx.doi.org/10.3390/v14112346
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