Cargando…

The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities

This is our second article devoted to the cardiac myoarchitecture considered as a nematic chiral liquid crystal (NCLC). While the first article focused on the myoarchitecture of the left ventricle (LV), this new article extends to the whole ventricular mass and introduces the concept of disclination...

Descripción completa

Detalles Bibliográficos
Autores principales: Auriau, Johanne, Usson, Yves, Jouk, Pierre-Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696617/
https://www.ncbi.nlm.nih.gov/pubmed/36354770
http://dx.doi.org/10.3390/jcdd9110371
_version_ 1784838355019628544
author Auriau, Johanne
Usson, Yves
Jouk, Pierre-Simon
author_facet Auriau, Johanne
Usson, Yves
Jouk, Pierre-Simon
author_sort Auriau, Johanne
collection PubMed
description This is our second article devoted to the cardiac myoarchitecture considered as a nematic chiral liquid crystal (NCLC). While the first article focused on the myoarchitecture of the left ventricle (LV), this new article extends to the whole ventricular mass and introduces the concept of disclinations and topological singularities, which characterize the differences and relationships between the left and right ventricles (RV). At the level of the ventricular apices, we constantly observed a vortex shape at the LV apex, corresponding, in the terminology of liquid crystals, to a “+1 disclination”; we never observed this at the RV apex. At the level of the interventricular septum (IVS), we identified “−1/2 disclinations” at the anterior and posterior parts. During the perinatal period, there was a significant difference in their distribution, with more “−1/2 disclinations” in the posterior part of the IVS. After birth, concomitant to major physiological changes, the number of “−1/2 disclinations” significantly decreased, both in the anterior and posterior parts of the IVS. Finally, the description of the disclinations must be considered in any attempt to segment the whole ventricular mass, in biomechanical studies, and, more generally, for the characterization of myocardial remodeling.
format Online
Article
Text
id pubmed-9696617
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96966172022-11-26 The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities Auriau, Johanne Usson, Yves Jouk, Pierre-Simon J Cardiovasc Dev Dis Article This is our second article devoted to the cardiac myoarchitecture considered as a nematic chiral liquid crystal (NCLC). While the first article focused on the myoarchitecture of the left ventricle (LV), this new article extends to the whole ventricular mass and introduces the concept of disclinations and topological singularities, which characterize the differences and relationships between the left and right ventricles (RV). At the level of the ventricular apices, we constantly observed a vortex shape at the LV apex, corresponding, in the terminology of liquid crystals, to a “+1 disclination”; we never observed this at the RV apex. At the level of the interventricular septum (IVS), we identified “−1/2 disclinations” at the anterior and posterior parts. During the perinatal period, there was a significant difference in their distribution, with more “−1/2 disclinations” in the posterior part of the IVS. After birth, concomitant to major physiological changes, the number of “−1/2 disclinations” significantly decreased, both in the anterior and posterior parts of the IVS. Finally, the description of the disclinations must be considered in any attempt to segment the whole ventricular mass, in biomechanical studies, and, more generally, for the characterization of myocardial remodeling. MDPI 2022-10-29 /pmc/articles/PMC9696617/ /pubmed/36354770 http://dx.doi.org/10.3390/jcdd9110371 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Auriau, Johanne
Usson, Yves
Jouk, Pierre-Simon
The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title_full The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title_fullStr The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title_full_unstemmed The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title_short The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities
title_sort nematic chiral liquid crystal structure of the cardiac myoarchitecture: disclinations and topological singularities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696617/
https://www.ncbi.nlm.nih.gov/pubmed/36354770
http://dx.doi.org/10.3390/jcdd9110371
work_keys_str_mv AT auriaujohanne thenematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities
AT ussonyves thenematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities
AT joukpierresimon thenematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities
AT auriaujohanne nematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities
AT ussonyves nematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities
AT joukpierresimon nematicchiralliquidcrystalstructureofthecardiacmyoarchitecturedisclinationsandtopologicalsingularities