Cargando…

The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia

Pneumocystis jiroveci remains an important fungal pathogen in immunocompromised hosts. The environmental reservoir remains unknown. Pneumonia (PJP) results from airborne transmission, including in nosocomial clusters, or with reactivation after an inadequately treated infection. Pneumocystis pneumon...

Descripción completa

Detalles Bibliográficos
Autores principales: Apostolopoulou, Anna, Fishman, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696632/
https://www.ncbi.nlm.nih.gov/pubmed/36354934
http://dx.doi.org/10.3390/jof8111167
_version_ 1784838358509289472
author Apostolopoulou, Anna
Fishman, Jay A.
author_facet Apostolopoulou, Anna
Fishman, Jay A.
author_sort Apostolopoulou, Anna
collection PubMed
description Pneumocystis jiroveci remains an important fungal pathogen in immunocompromised hosts. The environmental reservoir remains unknown. Pneumonia (PJP) results from airborne transmission, including in nosocomial clusters, or with reactivation after an inadequately treated infection. Pneumocystis pneumonia most often occurs within 6 months of organ transplantation, with intensified or prolonged immunosuppression, notably with corticosteroids and following cytomegalovirus (CMV) infections. Infection may be recognized during recovery from neutropenia and lymphopenia. Invasive procedures may be required for early diagnosis and therapy. Despite being a well-established entity, aspects of the pathogenesis of PJP remain poorly understood. The goal of this review is to summarize the data on the pathogenesis of PJP, review the strengths and weaknesses of the pertinent diagnostic modalities, and discuss areas for future research.
format Online
Article
Text
id pubmed-9696632
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96966322022-11-26 The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia Apostolopoulou, Anna Fishman, Jay A. J Fungi (Basel) Review Pneumocystis jiroveci remains an important fungal pathogen in immunocompromised hosts. The environmental reservoir remains unknown. Pneumonia (PJP) results from airborne transmission, including in nosocomial clusters, or with reactivation after an inadequately treated infection. Pneumocystis pneumonia most often occurs within 6 months of organ transplantation, with intensified or prolonged immunosuppression, notably with corticosteroids and following cytomegalovirus (CMV) infections. Infection may be recognized during recovery from neutropenia and lymphopenia. Invasive procedures may be required for early diagnosis and therapy. Despite being a well-established entity, aspects of the pathogenesis of PJP remain poorly understood. The goal of this review is to summarize the data on the pathogenesis of PJP, review the strengths and weaknesses of the pertinent diagnostic modalities, and discuss areas for future research. MDPI 2022-11-05 /pmc/articles/PMC9696632/ /pubmed/36354934 http://dx.doi.org/10.3390/jof8111167 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Apostolopoulou, Anna
Fishman, Jay A.
The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title_full The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title_fullStr The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title_full_unstemmed The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title_short The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia
title_sort pathogenesis and diagnosis of pneumocystis jiroveci pneumonia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696632/
https://www.ncbi.nlm.nih.gov/pubmed/36354934
http://dx.doi.org/10.3390/jof8111167
work_keys_str_mv AT apostolopoulouanna thepathogenesisanddiagnosisofpneumocystisjirovecipneumonia
AT fishmanjaya thepathogenesisanddiagnosisofpneumocystisjirovecipneumonia
AT apostolopoulouanna pathogenesisanddiagnosisofpneumocystisjirovecipneumonia
AT fishmanjaya pathogenesisanddiagnosisofpneumocystisjirovecipneumonia