Cidofovir for the Treatment of Molluscum Contagiosum Virus

That cidofovir, an acyclic nucleoside phosphonate (ANP), was inhibitory to the replication of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found to be inhibitory to the molluscum contagiosum (M. contagiosum) DNA polymerase was demonstrated b...

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Detalles Bibliográficos
Autor principal: De Clercq, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696735/
https://www.ncbi.nlm.nih.gov/pubmed/36366582
http://dx.doi.org/10.3390/v14112484
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author De Clercq, Erik
author_facet De Clercq, Erik
author_sort De Clercq, Erik
collection PubMed
description That cidofovir, an acyclic nucleoside phosphonate (ANP), was inhibitory to the replication of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found to be inhibitory to the molluscum contagiosum (M. contagiosum) DNA polymerase was demonstrated by Watanabe and Tamaki. Twelve different independent observations have then indicated that cidofovir administered intravenously, topically or intralesionally is efficacious in the treatment of M. contagiosum mostly in immunosuppressed patients.
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spelling pubmed-96967352022-11-26 Cidofovir for the Treatment of Molluscum Contagiosum Virus De Clercq, Erik Viruses Opinion That cidofovir, an acyclic nucleoside phosphonate (ANP), was inhibitory to the replication of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found to be inhibitory to the molluscum contagiosum (M. contagiosum) DNA polymerase was demonstrated by Watanabe and Tamaki. Twelve different independent observations have then indicated that cidofovir administered intravenously, topically or intralesionally is efficacious in the treatment of M. contagiosum mostly in immunosuppressed patients. MDPI 2022-11-10 /pmc/articles/PMC9696735/ /pubmed/36366582 http://dx.doi.org/10.3390/v14112484 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
De Clercq, Erik
Cidofovir for the Treatment of Molluscum Contagiosum Virus
title Cidofovir for the Treatment of Molluscum Contagiosum Virus
title_full Cidofovir for the Treatment of Molluscum Contagiosum Virus
title_fullStr Cidofovir for the Treatment of Molluscum Contagiosum Virus
title_full_unstemmed Cidofovir for the Treatment of Molluscum Contagiosum Virus
title_short Cidofovir for the Treatment of Molluscum Contagiosum Virus
title_sort cidofovir for the treatment of molluscum contagiosum virus
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696735/
https://www.ncbi.nlm.nih.gov/pubmed/36366582
http://dx.doi.org/10.3390/v14112484
work_keys_str_mv AT declercqerik cidofovirforthetreatmentofmolluscumcontagiosumvirus

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