Cargando…

Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations

COVID-19 is a terrible pandemic sweeping the whole world with more than 600 million confirmed cases and 6 million recorded deaths. Vaccination was identified as the sole option that could help in combatting the disease. In this study, SARS-CoV-2 antibodies were assessed in the saliva of vaccinated p...

Descripción completa

Detalles Bibliográficos
Autores principales: Sundar, Sandhya, Ramadoss, Ramya, Shanmugham, Rajeshkumar, Anandapadmanabhan, Lakshmi Trivandrum, Paneerselvam, Suganya, Ramani, Pratibha, Batul, Rumesa, Karobari, Mohmed Isaqali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696743/
https://www.ncbi.nlm.nih.gov/pubmed/36366328
http://dx.doi.org/10.3390/vaccines10111819
_version_ 1784838386850201600
author Sundar, Sandhya
Ramadoss, Ramya
Shanmugham, Rajeshkumar
Anandapadmanabhan, Lakshmi Trivandrum
Paneerselvam, Suganya
Ramani, Pratibha
Batul, Rumesa
Karobari, Mohmed Isaqali
author_facet Sundar, Sandhya
Ramadoss, Ramya
Shanmugham, Rajeshkumar
Anandapadmanabhan, Lakshmi Trivandrum
Paneerselvam, Suganya
Ramani, Pratibha
Batul, Rumesa
Karobari, Mohmed Isaqali
author_sort Sundar, Sandhya
collection PubMed
description COVID-19 is a terrible pandemic sweeping the whole world with more than 600 million confirmed cases and 6 million recorded deaths. Vaccination was identified as the sole option that could help in combatting the disease. In this study, SARS-CoV-2 antibodies were assessed in the saliva of vaccinated participants (Covaxin and Covishield) through enzyme-linked sorbent assay (ELISA). The IgG antibody titres in females were significantly greater than those of males. The total antibody titres of vaccinated individuals were greater than those of unvaccinated participants, although not statistically significant. Individuals who had completed both doses of vaccination had higher antibody levels than those who had received a single dose. People who had experienced COVID-19 after vaccination had better immunity compared to those who were unvaccinated with COVID-19 history. Thus, SARS-CoV-2 spike-specific antibodies were successfully demonstrated in saliva samples, and knowledge about the immunity triggered by the vaccines can assist in making informed choices.
format Online
Article
Text
id pubmed-9696743
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96967432022-11-26 Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations Sundar, Sandhya Ramadoss, Ramya Shanmugham, Rajeshkumar Anandapadmanabhan, Lakshmi Trivandrum Paneerselvam, Suganya Ramani, Pratibha Batul, Rumesa Karobari, Mohmed Isaqali Vaccines (Basel) Article COVID-19 is a terrible pandemic sweeping the whole world with more than 600 million confirmed cases and 6 million recorded deaths. Vaccination was identified as the sole option that could help in combatting the disease. In this study, SARS-CoV-2 antibodies were assessed in the saliva of vaccinated participants (Covaxin and Covishield) through enzyme-linked sorbent assay (ELISA). The IgG antibody titres in females were significantly greater than those of males. The total antibody titres of vaccinated individuals were greater than those of unvaccinated participants, although not statistically significant. Individuals who had completed both doses of vaccination had higher antibody levels than those who had received a single dose. People who had experienced COVID-19 after vaccination had better immunity compared to those who were unvaccinated with COVID-19 history. Thus, SARS-CoV-2 spike-specific antibodies were successfully demonstrated in saliva samples, and knowledge about the immunity triggered by the vaccines can assist in making informed choices. MDPI 2022-10-28 /pmc/articles/PMC9696743/ /pubmed/36366328 http://dx.doi.org/10.3390/vaccines10111819 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sundar, Sandhya
Ramadoss, Ramya
Shanmugham, Rajeshkumar
Anandapadmanabhan, Lakshmi Trivandrum
Paneerselvam, Suganya
Ramani, Pratibha
Batul, Rumesa
Karobari, Mohmed Isaqali
Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title_full Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title_fullStr Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title_full_unstemmed Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title_short Salivary Antibody Response of COVID-19 in Vaccinated and Unvaccinated Young Adult Populations
title_sort salivary antibody response of covid-19 in vaccinated and unvaccinated young adult populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696743/
https://www.ncbi.nlm.nih.gov/pubmed/36366328
http://dx.doi.org/10.3390/vaccines10111819
work_keys_str_mv AT sundarsandhya salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT ramadossramya salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT shanmughamrajeshkumar salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT anandapadmanabhanlakshmitrivandrum salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT paneerselvamsuganya salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT ramanipratibha salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT batulrumesa salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations
AT karobarimohmedisaqali salivaryantibodyresponseofcovid19invaccinatedandunvaccinatedyoungadultpopulations