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The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii
Among the medically most important snakes in the world, the species belonging to the genus Daboia have been attributed to the highest number of human envenomings, deaths and disabilities. Given their significant clinical relevance, the venoms of Russell’s vipers (D. russelii and D. siamensis) have b...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696752/ https://www.ncbi.nlm.nih.gov/pubmed/36355975 http://dx.doi.org/10.3390/toxins14110725 |
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author | Senji Laxme, R. R. Khochare, Suyog Attarde, Saurabh Kaur, Navneet Jaikumar, Priyanka Shaikh, Naeem Yusuf Aharoni, Reuven Primor, Naftali Hawlena, Dror Moran, Yehu Sunagar, Kartik |
author_facet | Senji Laxme, R. R. Khochare, Suyog Attarde, Saurabh Kaur, Navneet Jaikumar, Priyanka Shaikh, Naeem Yusuf Aharoni, Reuven Primor, Naftali Hawlena, Dror Moran, Yehu Sunagar, Kartik |
author_sort | Senji Laxme, R. R. |
collection | PubMed |
description | Among the medically most important snakes in the world, the species belonging to the genus Daboia have been attributed to the highest number of human envenomings, deaths and disabilities. Given their significant clinical relevance, the venoms of Russell’s vipers (D. russelii and D. siamensis) have been the primary focus of research. In contrast, the composition, activity, ecology and evolution of venom of its congener, the Palestine viper (D. palaestinae), have remained largely understudied. Therefore, to unravel the factors responsible for the enhanced medical relevance of D. russelii in comparison to D. palaestinae, we comparatively evaluated their venom proteomes, biochemical activities, and mortality and morbidity inflicting potentials. Furthermore, the synthesis and regulation of venom in snakes have also remained underinvestigated, and the relative contribution of each venom gland remains unclear. We address this knowledge gap by sequencing the tissue transcriptomes of both venom glands of D. palaestinae, and comparatively evaluating their contribution to the secreted venom concoction. Our findings highlight the disparity in the venom composition, function and toxicities of the two Daboia species. We also show that toxin production is not partitioned between the two venom glands of D. palaestinae. |
format | Online Article Text |
id | pubmed-9696752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96967522022-11-26 The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii Senji Laxme, R. R. Khochare, Suyog Attarde, Saurabh Kaur, Navneet Jaikumar, Priyanka Shaikh, Naeem Yusuf Aharoni, Reuven Primor, Naftali Hawlena, Dror Moran, Yehu Sunagar, Kartik Toxins (Basel) Article Among the medically most important snakes in the world, the species belonging to the genus Daboia have been attributed to the highest number of human envenomings, deaths and disabilities. Given their significant clinical relevance, the venoms of Russell’s vipers (D. russelii and D. siamensis) have been the primary focus of research. In contrast, the composition, activity, ecology and evolution of venom of its congener, the Palestine viper (D. palaestinae), have remained largely understudied. Therefore, to unravel the factors responsible for the enhanced medical relevance of D. russelii in comparison to D. palaestinae, we comparatively evaluated their venom proteomes, biochemical activities, and mortality and morbidity inflicting potentials. Furthermore, the synthesis and regulation of venom in snakes have also remained underinvestigated, and the relative contribution of each venom gland remains unclear. We address this knowledge gap by sequencing the tissue transcriptomes of both venom glands of D. palaestinae, and comparatively evaluating their contribution to the secreted venom concoction. Our findings highlight the disparity in the venom composition, function and toxicities of the two Daboia species. We also show that toxin production is not partitioned between the two venom glands of D. palaestinae. MDPI 2022-10-23 /pmc/articles/PMC9696752/ /pubmed/36355975 http://dx.doi.org/10.3390/toxins14110725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Senji Laxme, R. R. Khochare, Suyog Attarde, Saurabh Kaur, Navneet Jaikumar, Priyanka Shaikh, Naeem Yusuf Aharoni, Reuven Primor, Naftali Hawlena, Dror Moran, Yehu Sunagar, Kartik The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title | The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title_full | The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title_fullStr | The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title_full_unstemmed | The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title_short | The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii |
title_sort | middle eastern cousin: comparative venomics of daboia palaestinae and daboia russelii |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696752/ https://www.ncbi.nlm.nih.gov/pubmed/36355975 http://dx.doi.org/10.3390/toxins14110725 |
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