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VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis

Background: The aim of this study was to determine the predictive value of visual evoked potentials (VEPs) in patients with relapsing–remitting multiple sclerosis (RRMS) in achieving no evidence of disease activity-3 (NEDA-3) during up to 10 years of first-line immunomodulatory therapy and to determ...

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Autores principales: Miletic-Drakulic, Svetlana, Miloradovic, Ivana, Jankovic, Vladimir, Azanjac-Arsic, Ana, Lazarevic, Snezana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696926/
https://www.ncbi.nlm.nih.gov/pubmed/36433445
http://dx.doi.org/10.3390/s22228849
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author Miletic-Drakulic, Svetlana
Miloradovic, Ivana
Jankovic, Vladimir
Azanjac-Arsic, Ana
Lazarevic, Snezana
author_facet Miletic-Drakulic, Svetlana
Miloradovic, Ivana
Jankovic, Vladimir
Azanjac-Arsic, Ana
Lazarevic, Snezana
author_sort Miletic-Drakulic, Svetlana
collection PubMed
description Background: The aim of this study was to determine the predictive value of visual evoked potentials (VEPs) in patients with relapsing–remitting multiple sclerosis (RRMS) in achieving no evidence of disease activity-3 (NEDA-3) during up to 10 years of first-line immunomodulatory therapy and to determine whether the lateralization of optic nerve damage may have prognostic significance concerning clinical disability and response to therapy.Methods: In a retrospective study, a total of 83 patients (53 female and 30 male) with RRMS participated. The average age of patients was 38.31 ± 9.01. Patients were followed for 2, 5 or 10 years. VEPs were measured at the beginning of the follow-up and after many years of monitoring. Data on optical neuritis (ON) were obtained from medical history. The degree of disability was estimated by the neurologist (independent rater), and magnetic resonance (MR) imaging of the endocranium was performed with gadolinium contrasts. Achieving NEDA-3 is considered a favorable outcome of treatments.Results: Among those treated, 19 (22.9%) reached NEDA-3, while 64 (77.1%) did not reach NEDA-3. The values of the evoked potential (EP) score for the left eye (r = 0.008, odds ratio (OR) = 0.344 (0.156–0.757)) and latency for the left eye (r = 0.042, OR = 0.966 (0.934–0.999)) at the onset of disease were predictive factors for achieving NEDA-3. Conclusions: A normal VEP at the beginning of RRMS increases the chance of reaching NEDA-3 by about six times.
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spelling pubmed-96969262022-11-26 VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis Miletic-Drakulic, Svetlana Miloradovic, Ivana Jankovic, Vladimir Azanjac-Arsic, Ana Lazarevic, Snezana Sensors (Basel) Article Background: The aim of this study was to determine the predictive value of visual evoked potentials (VEPs) in patients with relapsing–remitting multiple sclerosis (RRMS) in achieving no evidence of disease activity-3 (NEDA-3) during up to 10 years of first-line immunomodulatory therapy and to determine whether the lateralization of optic nerve damage may have prognostic significance concerning clinical disability and response to therapy.Methods: In a retrospective study, a total of 83 patients (53 female and 30 male) with RRMS participated. The average age of patients was 38.31 ± 9.01. Patients were followed for 2, 5 or 10 years. VEPs were measured at the beginning of the follow-up and after many years of monitoring. Data on optical neuritis (ON) were obtained from medical history. The degree of disability was estimated by the neurologist (independent rater), and magnetic resonance (MR) imaging of the endocranium was performed with gadolinium contrasts. Achieving NEDA-3 is considered a favorable outcome of treatments.Results: Among those treated, 19 (22.9%) reached NEDA-3, while 64 (77.1%) did not reach NEDA-3. The values of the evoked potential (EP) score for the left eye (r = 0.008, odds ratio (OR) = 0.344 (0.156–0.757)) and latency for the left eye (r = 0.042, OR = 0.966 (0.934–0.999)) at the onset of disease were predictive factors for achieving NEDA-3. Conclusions: A normal VEP at the beginning of RRMS increases the chance of reaching NEDA-3 by about six times. MDPI 2022-11-16 /pmc/articles/PMC9696926/ /pubmed/36433445 http://dx.doi.org/10.3390/s22228849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miletic-Drakulic, Svetlana
Miloradovic, Ivana
Jankovic, Vladimir
Azanjac-Arsic, Ana
Lazarevic, Snezana
VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title_full VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title_fullStr VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title_full_unstemmed VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title_short VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis
title_sort vep score of a left eye had predictive values for achieving neda-3 over ten years in patients with multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696926/
https://www.ncbi.nlm.nih.gov/pubmed/36433445
http://dx.doi.org/10.3390/s22228849
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