Para-N-Methylpyridinium Pyrenes: Impact of Positive Charge on ds-DNA/RNA and Protein Recognition, Photo-Induced Bioactivity, and Intracellular Localisation

The 2- and 2,7- substituted para-N-methylpyridinium pyrene cations show high-affinity intercalation into ds-DNAs, whereas their non-methylated analogues interacted with ds-DNA/RNA only in the protonated form (at pH 5), but not at physiological conditions (pH 7). The fluorescence from non-methylated...

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Detalles Bibliográficos
Autores principales: Košćak, Marta, Pehar, Isabela, Božinović, Ksenija, Kole, Goutam Kumar, Sobočanec, Sandra, Podgorski, Iva I., Pinterić, Marija, Müller-Buschbaum, Klaus, Majhen, Dragomira, Piantanida, Ivo, Marder, Todd B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696974/
https://www.ncbi.nlm.nih.gov/pubmed/36432689
http://dx.doi.org/10.3390/pharmaceutics14112499

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