Cargando…

Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging

Aging affects the structure and function of the liver. Hydroxysafflor yellow A (HSYA) effectively improves liver aging (LA) in mice, but the potential mechanisms require further exploration. In this study, an integrated approach combining network pharmacology and transcriptomics was used to elucidat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Jie, Sun, Siming, Min, Fei, Hu, Xingli, Zhang, Yuan, Cheng, Yan, Li, Haiyan, Wang, Xiaojie, Liu, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697017/ https://www.ncbi.nlm.nih.gov/pubmed/36430769 http://dx.doi.org/10.3390/ijms232214281

Ejemplares similares

Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury
por: Li, Teng, et al.
Publicado: (2021)

Mechanism of hydroxysafflor yellow A on acute liver injury based on transcriptomics
por: Hou, Xiangmei, et al.
Publicado: (2022)

Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
por: Zhang, Xilan, et al.
Publicado: (2021)

Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A
por: Haiyan, CAO, et al.
Publicado: (2020)

Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects
por: Zhao, Feng, et al.
Publicado: (2020)

Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases
por: Bai, Xue, et al.
Publicado: (2020)

Nanoemulsions of Hydroxysafflor Yellow A for Enhancing Physicochemical and In Vivo Performance
por: Zhang, Yingjie, et al.
Publicado: (2023)

Hydroxysafflor yellow A protects against angiotensin II-induced hypertrophy
por: Ni, Bin, et al.
Publicado: (2018)

Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism
por: Pu, Weiling, et al.
Publicado: (2017)

Hydroxysafflor Yellow A Attenuates Lipopolysaccharide-Induced Neurotoxicity and Neuroinflammation in Primary Mesencephalic Cultures
por: Wang, Tian, et al.
Publicado: (2018)

Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression
por: Chen, Ziwei, et al.
Publicado: (2020)

Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A
por: Qi, Jianping, et al.
Publicado: (2011)

Hydroxysafflor Yellow A protects spinal cords from ischemia/reperfusion injury in rabbits
por: Shan, Le-qun, et al.
Publicado: (2010)

Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs
por: Wang, Xingtao, et al.
Publicado: (2016)

Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury
por: Dong, Fang, et al.
Publicado: (2017)

Hydroxysafflor Yellow A: A Promising Therapeutic Agent for a Broad Spectrum of Diseases
por: Ao, Hui, et al.
Publicado: (2018)

Hydroxysafflor Yellow A Shows Protection against PPARγ Inactivation in Nitrosative Neurons
por: Sun, Li, et al.
Publicado: (2018)

Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats
por: Han, Xiaotong, et al.
Publicado: (2016)

Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by d-galactose
por: Song, Xiaoqing, et al.
Publicado: (2022)

Protective effect of hydroxysafflor yellow A on renal ischemia‑reperfusion injury by targeting the Akt‑Nrf2 axis in mice
por: Wang, Yueming, et al.
Publicado: (2022)

Can ovarian aging be delayed by pharmacological strategies?
por: Zhang, Jinjin, et al.
Publicado: (2019)

Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy
por: Cao, Xu, et al.
Publicado: (2022)

Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury
por: Wang, Yang, et al.
Publicado: (2016)

Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats
por: Xu, Hang, et al.
Publicado: (2017)

Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway in rats
por: Sun, Zhihui, et al.
Publicado: (2022)

Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis
por: Ye, Jingxue, et al.
Publicado: (2021)

Protective potential of hydroxysafflor yellow A in cerebral ischemia and reperfusion injury: An overview of evidence from experimental studies
por: Yu, Lu, et al.
Publicado: (2022)

Hydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling
por: Han, Dan, et al.
Publicado: (2016)

Proteomic investigation of effects of hydroxysafflor yellow A in oxidized low-density lipoprotein-induced endothelial injury
por: Ye, Feng, et al.
Publicado: (2017)

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis
por: Gao, Si-Qian, et al.
Publicado: (2018)

Protective effect of hydroxysafflor yellow A on cyclosporin A-induced renal oxidative stress in vitro and in vivo
por: Wang, Jiyuan, et al.
Publicado: (2022)

Oral Bioavailability-Enhancing and Anti-obesity Effects of Hydroxysafflor Yellow A in Natural Deep Eutectic Solvent
por: Gao, Huan, et al.
Publicado: (2022)

Hydroxysafflor Yellow A Phytosomes Administered via Intervaginal Space Injection Ameliorate Pulmonary Fibrosis in Mice
por: Li, Tingting, et al.
Publicado: (2022)

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression
por: He, Junhui, et al.
Publicado: (2023)

Integrating systematic pharmacology-based strategy and experimental validation to explore mechanism of Tripterygium glycoside on cholangiocyte-related liver injury
por: Li, Yajing, et al.
Publicado: (2022)

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition
por: Hu, Naping, et al.
Publicado: (2016)

Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis
por: Liu, Li, et al.
Publicado: (2018)

Hydroxysafflor Yellow A Suppresses Platelet Activating Factor-Induced Activation of Human Small Airway Epithelial Cells
por: Guo, Xinjing, et al.
Publicado: (2018)

Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
por: Bai, Yuhua, et al.
Publicado: (2012)

Hydroxysafflor Yellow A Attenuates the Apoptosis of Peripheral Blood CD4(+) T Lymphocytes in a Murine Model of Sepsis
por: Wang, Jinping, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_95uipioel42mjgqjfphp0moaum