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Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications

Plant-derived polyphenolic chemicals are important components of human nutrition and have been found to have chemotherapeutic effects against a variety of cancers. Several studies in animal models have proven polyphenols’ potential to promote apoptosis and tumor regression. However, the method by wh...

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Detalles Bibliográficos
Autor principal: Farhan, Mohd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697029/
https://www.ncbi.nlm.nih.gov/pubmed/36422562
http://dx.doi.org/10.3390/ph15111431
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author Farhan, Mohd
author_facet Farhan, Mohd
author_sort Farhan, Mohd
collection PubMed
description Plant-derived polyphenolic chemicals are important components of human nutrition and have been found to have chemotherapeutic effects against a variety of cancers. Several studies in animal models have proven polyphenols’ potential to promote apoptosis and tumor regression. However, the method by which polyphenols show their anticancer effects on malignant cells is not well understood. It is generally known that cellular copper rises within malignant cells and in the serum of cancer patients. In this communication, investigations reveal that naringin (a polyphenol found in citrus fruits) can strongly suppress cell proliferation and trigger apoptosis in various cancer cell lines in the presence of copper ions. The cuprous chelator neocuproine, which confirms copper-mediated DNA damage, prevents such cell death to a large extent. The studies further show that the cellular copper transporters CTR1 and ATP7A have a role in the survival dynamics of malignant cells after naringin exposure. The findings emphasize the crucial function of copper dynamics and mobilization in cancer cells and pave the path for a better understanding of polyphenols as nutraceutical supplements for cancer prevention and treatment.
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spelling pubmed-96970292022-11-26 Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications Farhan, Mohd Pharmaceuticals (Basel) Communication Plant-derived polyphenolic chemicals are important components of human nutrition and have been found to have chemotherapeutic effects against a variety of cancers. Several studies in animal models have proven polyphenols’ potential to promote apoptosis and tumor regression. However, the method by which polyphenols show their anticancer effects on malignant cells is not well understood. It is generally known that cellular copper rises within malignant cells and in the serum of cancer patients. In this communication, investigations reveal that naringin (a polyphenol found in citrus fruits) can strongly suppress cell proliferation and trigger apoptosis in various cancer cell lines in the presence of copper ions. The cuprous chelator neocuproine, which confirms copper-mediated DNA damage, prevents such cell death to a large extent. The studies further show that the cellular copper transporters CTR1 and ATP7A have a role in the survival dynamics of malignant cells after naringin exposure. The findings emphasize the crucial function of copper dynamics and mobilization in cancer cells and pave the path for a better understanding of polyphenols as nutraceutical supplements for cancer prevention and treatment. MDPI 2022-11-19 /pmc/articles/PMC9697029/ /pubmed/36422562 http://dx.doi.org/10.3390/ph15111431 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Farhan, Mohd
Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title_full Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title_fullStr Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title_full_unstemmed Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title_short Naringin’s Prooxidant Effect on Tumor Cells: Copper’s Role and Therapeutic Implications
title_sort naringin’s prooxidant effect on tumor cells: copper’s role and therapeutic implications
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697029/
https://www.ncbi.nlm.nih.gov/pubmed/36422562
http://dx.doi.org/10.3390/ph15111431
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