Cargando…

Mitochondrial Alterations in Neurons Derived from the Murine App(NL-F) Knock-In Model of Alzheimer’s Disease

BACKGROUND: Alzheimer’s disease (AD) research has relied on mouse models overexpressing human mutant A βPP; however, newer generation knock-in models allow for physiological expression of amyloid-β protein precursor (AβPP) containing familial AD mutations where murine AβPP is edited with a humanized...

Descripción completa

Detalles Bibliográficos
Autores principales: Dentoni, Giacomo, Naia, Luana, Portal, Benjamin, Leal, Nuno Santos, Nilsson, Per, Lindskog, Maria, Ankarcrona, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697055/
https://www.ncbi.nlm.nih.gov/pubmed/36155507
http://dx.doi.org/10.3233/JAD-220383