Design and Evaluation of Novel HIV-1 Protease Inhibitors Containing Phenols or Polyphenols as P2 Ligands with High Activity against DRV-Resistant HIV-1 Variants

With the increasing prevalence of drug-resistant variants, novel potent HIV-1 protease inhibitors with broad-spectrum antiviral activity against multidrug-resistant causative viruses are urgently needed. Herein, we designed and synthesized a new series of HIV-1 protease inhibitors with phenols or po...

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Detalles Bibliográficos
Autores principales: Ma, Ling, Wen, Jiajia, Dong, Biao, Zhou, Jinming, Hu, Shangjiu, Wang, Juxian, Wang, Yucheng, Zhu, Mei, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697080/
https://www.ncbi.nlm.nih.gov/pubmed/36430656
http://dx.doi.org/10.3390/ijms232214178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697080/
https://www.ncbi.nlm.nih.gov/pubmed/36430656
http://dx.doi.org/10.3390/ijms232214178

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