Cargando…

The Protective Effect of Zebularine, an Inhibitor of DNA Methyltransferase, on Renal Tubulointerstitial Inflammation and Fibrosis

Renal fibrosis, the final pathway of chronic kidney disease, is caused by genetic and epigenetic mechanisms. Although DNA methylation has drawn attention as a developing mechanism of renal fibrosis, its contribution to renal fibrosis has not been clarified. To address this issue, the effect of zebul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koh, Eun Sil, Kim, Soojeong, Son, Mina, Park, Ji-Young, Pyo, Jaehyuk, Kim, Wan-Young, Kim, Minyoung, Chung, Sungjin, Park, Cheol Whee, Kim, Ho-Shik, Shin, Seok Joon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697081/ https://www.ncbi.nlm.nih.gov/pubmed/36430531 http://dx.doi.org/10.3390/ijms232214045

Ejemplares similares

Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2
por: Chung, Sungjin, et al.
Publicado: (2019)

Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin
por: Chung, Sungjin, et al.
Publicado: (2017)

Correction: Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin
por: Chung, Sungjin, et al.
Publicado: (2018)

D-Pinitol alleviates cyclosporine A-induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways
por: Koh, Eun Sil, et al.
Publicado: (2018)

Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling
por: Hong, Yu Ah, et al.
Publicado: (2014)

Empagliflozin Contributes to Polyuria via Regulation of Sodium Transporters and Water Channels in Diabetic Rat Kidneys
por: Chung, Sungjin, et al.
Publicado: (2019)

Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis
por: Chung, Sungjin, et al.
Publicado: (2021)

Fimasartan, a Novel Angiotensin-Receptor Blocker, Protects against Renal Inflammation and Fibrosis in Mice with Unilateral Ureteral Obstruction: the Possible Role of Nrf2
por: Kim, Soojeong, et al.
Publicado: (2015)

Identification of a novel GLA mutation (Y88C) in a Korean family with Fabry nephropathy: a case report
por: Chong, Yosep, et al.
Publicado: (2016)

Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases
por: Chung, Sungjin, et al.
Publicado: (2017)

Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine
por: Champion, Christine, et al.
Publicado: (2010)

Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2
por: Chung, Sungjin, et al.
Publicado: (2014)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique
por: Chung, Sungjin, et al.
Publicado: (2014)

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis
por: Seo, Eunjeong, et al.
Publicado: (2016)

Altered Metabolism of Blood Manganese Is Associated with Low Levels of Hemoglobin in Patients with Chronic Kidney Disease
por: Kim, Minyoung, et al.
Publicado: (2017)

Effects of a novel DNA methyltransferase inhibitor Zebularine on human lens epithelial cells
por: Zhou, Peng, et al.
Publicado: (2012)

Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
por: Koh, Eun Sil, et al.
Publicado: (2014)

DNA Methyltransferase Inhibitor Zebularine Inhibits Human Hepatic Carcinoma Cells Proliferation and Induces Apoptosis
por: Nakamura, Kazuaki, et al.
Publicado: (2013)

Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice
por: Koh, Eun Sil, et al.
Publicado: (2015)

Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis
por: Jin, Jixiu, et al.
Publicado: (2020)

Induction of DR5-Dependent Apoptosis by PGA(2) through ATF4-CHOP Pathway
por: Park, Kyeong-Min, et al.
Publicado: (2022)

Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice
por: Choi, Arum, et al.
Publicado: (2018)

Renal Outcome of IgM Nephropathy: A Comparative Prospective Cohort Study
por: Chae, Yura, et al.
Publicado: (2021)

Protein arginine methyltransferase 3 inhibits renal tubulointerstitial fibrosis through asymmetric dimethylarginine
por: Wang, Yanzhe, et al.
Publicado: (2022)

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice
por: Nguyễn-Thanh, Tùng, et al.
Publicado: (2018)

DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status
por: Nakamura, Kazuaki, et al.
Publicado: (2015)

The Impact of the Aortic Pulse Wave Velocity on the Cardiovascular Outcomes of Hemodialysis Patients
por: Shin, Seok Joon, et al.
Publicado: (2009)

Eucalyptol ameliorates Snail1/β-catenin-dependent diabetic disjunction of renal tubular epithelial cells and tubulointerstitial fibrosis
por: Kim, Dong Yeon, et al.
Publicado: (2017)

Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy
por: Chung, Sungjin, et al.
Publicado: (2011)

A Case of Acute Tubulointerstitial Nephritis Associated with Rifampin Therapy Presenting as Fanconi-like Syndrome
por: Park, Jun Tae, et al.
Publicado: (2017)

The Prognostic Value of Abdominal Aortic Calcification in Peritoneal Dialysis Patients
por: Yoon, Hye Eun, et al.
Publicado: (2013)

Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis
por: Yun, Donghwan, et al.
Publicado: (2019)

Intramural duodenal hematoma and hemoperitoneum after endoscopic treatment in a patient with chronic renal failure on hemodialysis: a case report
por: Chung, Sungjin, et al.
Publicado: (2009)

Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in db/db Mice
por: Whee Park, Cheol, et al.
Publicado: (2009)

Is the proximal tubule the focus of tubulointerstitial fibrosis?
por: Peng, Zhi, et al.
Publicado: (2023)

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
por: Nam, Sun Ah, et al.
Publicado: (2019)

Kidney VISTA prevents IFN-γ/IL-9 axis–mediated tubulointerstitial fibrosis after acute glomerular injury
por: Kim, Min-Gang, et al.
Publicado: (2022)

Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease tubulointerstitial fibrosis in unilateral ureteral obstruction
por: Choi, Hoon Young, et al.
Publicado: (2015)

Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure
por: Konečná, Klára, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jemjrs5kdhvi79j9v2atigojiu