Cargando…
A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population
Growing research data suggests that the severity of COVID-19 is linked with higher levels of inflammatory mediators, such as cytokines, chemokines, tumor necrosis factor, C-reactive protein, ferritin, and D-dimers. In addition, it was evident from the existing research data that the severity of SARS...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697185/ https://www.ncbi.nlm.nih.gov/pubmed/36431254 http://dx.doi.org/10.3390/jcm11226777 |
_version_ | 1784838497763328000 |
---|---|
author | Mocanu, Alexandra Lazureanu, Voichita Elena Marinescu, Adelina Raluca Cut, Talida Georgiana Laza, Ruxandra Rusu, Laura-Cristina Marza, Adina Maria Nelson-Twakor, Andreea Negrean, Rodica Anamaria Popescu, Irina-Maria Mederle, Alexandru Ovidiu |
author_facet | Mocanu, Alexandra Lazureanu, Voichita Elena Marinescu, Adelina Raluca Cut, Talida Georgiana Laza, Ruxandra Rusu, Laura-Cristina Marza, Adina Maria Nelson-Twakor, Andreea Negrean, Rodica Anamaria Popescu, Irina-Maria Mederle, Alexandru Ovidiu |
author_sort | Mocanu, Alexandra |
collection | PubMed |
description | Growing research data suggests that the severity of COVID-19 is linked with higher levels of inflammatory mediators, such as cytokines, chemokines, tumor necrosis factor, C-reactive protein, ferritin, and D-dimers. In addition, it was evident from the existing research data that the severity of SARS-CoV-2 infection differs according to independent risk factors such as race and ethnicity. Some scarce evidence shows that the European Roma community is likely to be at an elevated risk of illness and death during the pandemic due to their lifestyle, social factors, and economics. Assuming that precautions must be taken to protect this population from coronavirus infections and from widening existing disparities in comparison with the Romanian ethnic population, the current study aimed to observe the clinical evolution of the Roma patients with severe SARS-CoV-2 infection in correlation with the laboratory findings and inflammatory markers involved. After calculating the sample size requirements, we included 83 Roma patients admitted to the hospital with severe COVID-19 and 236 patients of Romanian ethnicity with the same inclusion criteria. Patients were selected from the period stretching from March 2020 to December 2021, before COVID-19 vaccines were introduced. Compared with the general population, the Roma patients with severe SARS-CoV-2 infection had a higher unemployment rate (39.8%), and most of them were residing in rural regions (65.4%). There were significantly more overweight patients in the Roma group than in the control group (57.8% vs. 40.7%), and it was also observed that high blood pressure and diabetes mellitus were significantly more prevalent in the Roma patients. They had significantly longer mean duration of hospitalization was significantly longer in the group of Roma patients (18.1 days vs. 16.3 days). IL-6 and CRP levels were significantly more elevated during admission in the group of Roma patients (43.4% vs. 28.4%); however, IL-6 levels normalized at discharge, but ESR remained high. Although ICU admissions were significantly more frequent in this group, the mortality rate was not significantly higher than in the general population. It is necessary to plan different healthcare strategies aimed at special populations, such as the Roma ethnicity to prevent disparities in negative outcomes reflected in this study. The results imply that community-health collaborations between organizations of minority groups and healthcare professionals can mitigate the disproportionate consequences of the pandemic on Roma. |
format | Online Article Text |
id | pubmed-9697185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96971852022-11-26 A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population Mocanu, Alexandra Lazureanu, Voichita Elena Marinescu, Adelina Raluca Cut, Talida Georgiana Laza, Ruxandra Rusu, Laura-Cristina Marza, Adina Maria Nelson-Twakor, Andreea Negrean, Rodica Anamaria Popescu, Irina-Maria Mederle, Alexandru Ovidiu J Clin Med Article Growing research data suggests that the severity of COVID-19 is linked with higher levels of inflammatory mediators, such as cytokines, chemokines, tumor necrosis factor, C-reactive protein, ferritin, and D-dimers. In addition, it was evident from the existing research data that the severity of SARS-CoV-2 infection differs according to independent risk factors such as race and ethnicity. Some scarce evidence shows that the European Roma community is likely to be at an elevated risk of illness and death during the pandemic due to their lifestyle, social factors, and economics. Assuming that precautions must be taken to protect this population from coronavirus infections and from widening existing disparities in comparison with the Romanian ethnic population, the current study aimed to observe the clinical evolution of the Roma patients with severe SARS-CoV-2 infection in correlation with the laboratory findings and inflammatory markers involved. After calculating the sample size requirements, we included 83 Roma patients admitted to the hospital with severe COVID-19 and 236 patients of Romanian ethnicity with the same inclusion criteria. Patients were selected from the period stretching from March 2020 to December 2021, before COVID-19 vaccines were introduced. Compared with the general population, the Roma patients with severe SARS-CoV-2 infection had a higher unemployment rate (39.8%), and most of them were residing in rural regions (65.4%). There were significantly more overweight patients in the Roma group than in the control group (57.8% vs. 40.7%), and it was also observed that high blood pressure and diabetes mellitus were significantly more prevalent in the Roma patients. They had significantly longer mean duration of hospitalization was significantly longer in the group of Roma patients (18.1 days vs. 16.3 days). IL-6 and CRP levels were significantly more elevated during admission in the group of Roma patients (43.4% vs. 28.4%); however, IL-6 levels normalized at discharge, but ESR remained high. Although ICU admissions were significantly more frequent in this group, the mortality rate was not significantly higher than in the general population. It is necessary to plan different healthcare strategies aimed at special populations, such as the Roma ethnicity to prevent disparities in negative outcomes reflected in this study. The results imply that community-health collaborations between organizations of minority groups and healthcare professionals can mitigate the disproportionate consequences of the pandemic on Roma. MDPI 2022-11-16 /pmc/articles/PMC9697185/ /pubmed/36431254 http://dx.doi.org/10.3390/jcm11226777 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mocanu, Alexandra Lazureanu, Voichita Elena Marinescu, Adelina Raluca Cut, Talida Georgiana Laza, Ruxandra Rusu, Laura-Cristina Marza, Adina Maria Nelson-Twakor, Andreea Negrean, Rodica Anamaria Popescu, Irina-Maria Mederle, Alexandru Ovidiu A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title | A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title_full | A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title_fullStr | A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title_full_unstemmed | A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title_short | A Retrospective Assessment of Laboratory Findings and Cytokine Markers in Severe SARS-CoV-2 Infection among Patients of Roma Population |
title_sort | retrospective assessment of laboratory findings and cytokine markers in severe sars-cov-2 infection among patients of roma population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697185/ https://www.ncbi.nlm.nih.gov/pubmed/36431254 http://dx.doi.org/10.3390/jcm11226777 |
work_keys_str_mv | AT mocanualexandra aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT lazureanuvoichitaelena aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT marinescuadelinaraluca aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT cuttalidageorgiana aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT lazaruxandra aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT rusulauracristina aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT marzaadinamaria aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT nelsontwakorandreea aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT negreanrodicaanamaria aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT popescuirinamaria aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT mederlealexandruovidiu aretrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT mocanualexandra retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT lazureanuvoichitaelena retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT marinescuadelinaraluca retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT cuttalidageorgiana retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT lazaruxandra retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT rusulauracristina retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT marzaadinamaria retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT nelsontwakorandreea retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT negreanrodicaanamaria retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT popescuirinamaria retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation AT mederlealexandruovidiu retrospectiveassessmentoflaboratoryfindingsandcytokinemarkersinseveresarscov2infectionamongpatientsofromapopulation |