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The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats

Sulfonamides are among the most used drugs in beekeeping due to their effectiveness, despite their long-term persistence in tissues. Bee honey containing such residues poses numerous risks to human health. The aim of the study was to evaluate the effects on immunological and hematological parameters...

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Autores principales: Morariu, Ionela Daniela, Avasilcai, Liliana, Cioanca, Oana, Morariu, Branco-Adrian, Vieriu, Madalina, Tanase, Corneliu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697197/
https://www.ncbi.nlm.nih.gov/pubmed/36363515
http://dx.doi.org/10.3390/medicina58111558
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author Morariu, Ionela Daniela
Avasilcai, Liliana
Cioanca, Oana
Morariu, Branco-Adrian
Vieriu, Madalina
Tanase, Corneliu
author_facet Morariu, Ionela Daniela
Avasilcai, Liliana
Cioanca, Oana
Morariu, Branco-Adrian
Vieriu, Madalina
Tanase, Corneliu
author_sort Morariu, Ionela Daniela
collection PubMed
description Sulfonamides are among the most used drugs in beekeeping due to their effectiveness, despite their long-term persistence in tissues. Bee honey containing such residues poses numerous risks to human health. The aim of the study was to evaluate the effects on immunological and hematological parameters of Wistar rats produced by sulfonamide residues in bee honey, through the evaluation of various blood parameters such as triiodothyronine and thyroxine levels, hematocrit, hemoglobin, red blood cell count and mean corpuscular hemoglobin concentration in a given volume of erythrocytes following administration of sulfonamide-containing honey. The hematological and immunological parameters showed significant variations in the group of rats that had been fed with honey spiked with sulfonamides compared to the control group. Changes in hematological indices were demonstrated in terms of a significant reduction in the number of erythrocytes, the amount of hemoglobin, and the value of hematocrit, thus confirming the induction of anemia in the tested group. Investigation of thyroid function through the analysis of triiodothyronine (T3) and thyroxine (T4) and their ratio showed a very significant decrease in plasma thyroxine levels in laboratory rats that were fed sulfonamide-spiked honey compared to the control group. The mean T3 concentration decreased from 0.70 ± 0.14 ng/dL to 0.34 ± 0.03 ng/dL, while the mean T4 concentration was reduced from 4.50 ± 0.30 μg/dL to 3.32 ± 0.21 μg/dL, thus demonstrating toxic effects on thyroid function. In sum, the presence of sulfonamides induced significant changes in the evaluated parameters indicating that the consumption of contaminated honey samples represents a high risk factor for thyroid dysfunction with potentially serious health impacts.
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spelling pubmed-96971972022-11-26 The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats Morariu, Ionela Daniela Avasilcai, Liliana Cioanca, Oana Morariu, Branco-Adrian Vieriu, Madalina Tanase, Corneliu Medicina (Kaunas) Article Sulfonamides are among the most used drugs in beekeeping due to their effectiveness, despite their long-term persistence in tissues. Bee honey containing such residues poses numerous risks to human health. The aim of the study was to evaluate the effects on immunological and hematological parameters of Wistar rats produced by sulfonamide residues in bee honey, through the evaluation of various blood parameters such as triiodothyronine and thyroxine levels, hematocrit, hemoglobin, red blood cell count and mean corpuscular hemoglobin concentration in a given volume of erythrocytes following administration of sulfonamide-containing honey. The hematological and immunological parameters showed significant variations in the group of rats that had been fed with honey spiked with sulfonamides compared to the control group. Changes in hematological indices were demonstrated in terms of a significant reduction in the number of erythrocytes, the amount of hemoglobin, and the value of hematocrit, thus confirming the induction of anemia in the tested group. Investigation of thyroid function through the analysis of triiodothyronine (T3) and thyroxine (T4) and their ratio showed a very significant decrease in plasma thyroxine levels in laboratory rats that were fed sulfonamide-spiked honey compared to the control group. The mean T3 concentration decreased from 0.70 ± 0.14 ng/dL to 0.34 ± 0.03 ng/dL, while the mean T4 concentration was reduced from 4.50 ± 0.30 μg/dL to 3.32 ± 0.21 μg/dL, thus demonstrating toxic effects on thyroid function. In sum, the presence of sulfonamides induced significant changes in the evaluated parameters indicating that the consumption of contaminated honey samples represents a high risk factor for thyroid dysfunction with potentially serious health impacts. MDPI 2022-10-30 /pmc/articles/PMC9697197/ /pubmed/36363515 http://dx.doi.org/10.3390/medicina58111558 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morariu, Ionela Daniela
Avasilcai, Liliana
Cioanca, Oana
Morariu, Branco-Adrian
Vieriu, Madalina
Tanase, Corneliu
The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title_full The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title_fullStr The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title_full_unstemmed The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title_short The Effects of Honey Sulfonamides on Immunological and Hematological Parameters in Wistar Rats
title_sort effects of honey sulfonamides on immunological and hematological parameters in wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697197/
https://www.ncbi.nlm.nih.gov/pubmed/36363515
http://dx.doi.org/10.3390/medicina58111558
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