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Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone

It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants...

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Autores principales: Tuli, Hardeep Singh, Kumar, Ajay, Sak, Katrin, Aggarwal, Diwakar, Gupta, Dhruv Sanjay, Kaur, Ginpreet, Vashishth, Kanupriya, Dhama, Kuldeep, Kaur, Jagjit, Saini, Adesh K., Varol, Mehmet, Capanoglu, Esra, Haque, Shafiul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697248/
https://www.ncbi.nlm.nih.gov/pubmed/36422548
http://dx.doi.org/10.3390/ph15111418
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author Tuli, Hardeep Singh
Kumar, Ajay
Sak, Katrin
Aggarwal, Diwakar
Gupta, Dhruv Sanjay
Kaur, Ginpreet
Vashishth, Kanupriya
Dhama, Kuldeep
Kaur, Jagjit
Saini, Adesh K.
Varol, Mehmet
Capanoglu, Esra
Haque, Shafiul
author_facet Tuli, Hardeep Singh
Kumar, Ajay
Sak, Katrin
Aggarwal, Diwakar
Gupta, Dhruv Sanjay
Kaur, Ginpreet
Vashishth, Kanupriya
Dhama, Kuldeep
Kaur, Jagjit
Saini, Adesh K.
Varol, Mehmet
Capanoglu, Esra
Haque, Shafiul
author_sort Tuli, Hardeep Singh
collection PubMed
description It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants, flavonoids. In this review article, suppressing effects of equol in different carcinogenesis models are unraveled, highlighting the mechanisms involved in these anticancer activities. Among flavonoids, daidzein is a well-known isoflavone occurring in soybeans and soy products. In a certain part of population, this soy isoflavone is decomposed to equol under the action of gut microflora. Somewhat surprisingly, this degradation product has been shown to be more bioactive than its precursor daidzein, revealing a strong and multifaceted anticancer potential. In this way, it is important to bear in mind that the metabolic conversion of plant flavonoids might lead to products that are even more efficient than the parent compounds themselves, definitely deserving further studies.
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spelling pubmed-96972482022-11-26 Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone Tuli, Hardeep Singh Kumar, Ajay Sak, Katrin Aggarwal, Diwakar Gupta, Dhruv Sanjay Kaur, Ginpreet Vashishth, Kanupriya Dhama, Kuldeep Kaur, Jagjit Saini, Adesh K. Varol, Mehmet Capanoglu, Esra Haque, Shafiul Pharmaceuticals (Basel) Review It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants, flavonoids. In this review article, suppressing effects of equol in different carcinogenesis models are unraveled, highlighting the mechanisms involved in these anticancer activities. Among flavonoids, daidzein is a well-known isoflavone occurring in soybeans and soy products. In a certain part of population, this soy isoflavone is decomposed to equol under the action of gut microflora. Somewhat surprisingly, this degradation product has been shown to be more bioactive than its precursor daidzein, revealing a strong and multifaceted anticancer potential. In this way, it is important to bear in mind that the metabolic conversion of plant flavonoids might lead to products that are even more efficient than the parent compounds themselves, definitely deserving further studies. MDPI 2022-11-16 /pmc/articles/PMC9697248/ /pubmed/36422548 http://dx.doi.org/10.3390/ph15111418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tuli, Hardeep Singh
Kumar, Ajay
Sak, Katrin
Aggarwal, Diwakar
Gupta, Dhruv Sanjay
Kaur, Ginpreet
Vashishth, Kanupriya
Dhama, Kuldeep
Kaur, Jagjit
Saini, Adesh K.
Varol, Mehmet
Capanoglu, Esra
Haque, Shafiul
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title_full Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title_fullStr Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title_full_unstemmed Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title_short Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
title_sort gut microbiota-assisted synthesis, cellular interactions and synergistic perspectives of equol as a potent anticancer isoflavone
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697248/
https://www.ncbi.nlm.nih.gov/pubmed/36422548
http://dx.doi.org/10.3390/ph15111418
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