Cargando…
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697248/ https://www.ncbi.nlm.nih.gov/pubmed/36422548 http://dx.doi.org/10.3390/ph15111418 |
_version_ | 1784838513957535744 |
---|---|
author | Tuli, Hardeep Singh Kumar, Ajay Sak, Katrin Aggarwal, Diwakar Gupta, Dhruv Sanjay Kaur, Ginpreet Vashishth, Kanupriya Dhama, Kuldeep Kaur, Jagjit Saini, Adesh K. Varol, Mehmet Capanoglu, Esra Haque, Shafiul |
author_facet | Tuli, Hardeep Singh Kumar, Ajay Sak, Katrin Aggarwal, Diwakar Gupta, Dhruv Sanjay Kaur, Ginpreet Vashishth, Kanupriya Dhama, Kuldeep Kaur, Jagjit Saini, Adesh K. Varol, Mehmet Capanoglu, Esra Haque, Shafiul |
author_sort | Tuli, Hardeep Singh |
collection | PubMed |
description | It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants, flavonoids. In this review article, suppressing effects of equol in different carcinogenesis models are unraveled, highlighting the mechanisms involved in these anticancer activities. Among flavonoids, daidzein is a well-known isoflavone occurring in soybeans and soy products. In a certain part of population, this soy isoflavone is decomposed to equol under the action of gut microflora. Somewhat surprisingly, this degradation product has been shown to be more bioactive than its precursor daidzein, revealing a strong and multifaceted anticancer potential. In this way, it is important to bear in mind that the metabolic conversion of plant flavonoids might lead to products that are even more efficient than the parent compounds themselves, definitely deserving further studies. |
format | Online Article Text |
id | pubmed-9697248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96972482022-11-26 Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone Tuli, Hardeep Singh Kumar, Ajay Sak, Katrin Aggarwal, Diwakar Gupta, Dhruv Sanjay Kaur, Ginpreet Vashishth, Kanupriya Dhama, Kuldeep Kaur, Jagjit Saini, Adesh K. Varol, Mehmet Capanoglu, Esra Haque, Shafiul Pharmaceuticals (Basel) Review It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of structurally different phytochemicals, including polyphenolic constituents of plants, flavonoids. In this review article, suppressing effects of equol in different carcinogenesis models are unraveled, highlighting the mechanisms involved in these anticancer activities. Among flavonoids, daidzein is a well-known isoflavone occurring in soybeans and soy products. In a certain part of population, this soy isoflavone is decomposed to equol under the action of gut microflora. Somewhat surprisingly, this degradation product has been shown to be more bioactive than its precursor daidzein, revealing a strong and multifaceted anticancer potential. In this way, it is important to bear in mind that the metabolic conversion of plant flavonoids might lead to products that are even more efficient than the parent compounds themselves, definitely deserving further studies. MDPI 2022-11-16 /pmc/articles/PMC9697248/ /pubmed/36422548 http://dx.doi.org/10.3390/ph15111418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tuli, Hardeep Singh Kumar, Ajay Sak, Katrin Aggarwal, Diwakar Gupta, Dhruv Sanjay Kaur, Ginpreet Vashishth, Kanupriya Dhama, Kuldeep Kaur, Jagjit Saini, Adesh K. Varol, Mehmet Capanoglu, Esra Haque, Shafiul Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title | Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title_full | Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title_fullStr | Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title_full_unstemmed | Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title_short | Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone |
title_sort | gut microbiota-assisted synthesis, cellular interactions and synergistic perspectives of equol as a potent anticancer isoflavone |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697248/ https://www.ncbi.nlm.nih.gov/pubmed/36422548 http://dx.doi.org/10.3390/ph15111418 |
work_keys_str_mv | AT tulihardeepsingh gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT kumarajay gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT sakkatrin gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT aggarwaldiwakar gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT guptadhruvsanjay gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT kaurginpreet gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT vashishthkanupriya gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT dhamakuldeep gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT kaurjagjit gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT sainiadeshk gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT varolmehmet gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT capanogluesra gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone AT haqueshafiul gutmicrobiotaassistedsynthesiscellularinteractionsandsynergisticperspectivesofequolasapotentanticancerisoflavone |