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Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy

Antiretroviral therapy (ART) improves the quality of life of people living with HIV-1 (PLHIV) and reduces the mortality rate, but some individuals may develop metabolic abnormalities. This study evaluated changes in the nutritional status and biochemistry of PLHIV on antiretroviral therapy in a coho...

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Autores principales: de Souza, Ranilda Gama, Lima, Sandra Souza, Pinto, Andresa Corrêa, Souza, Jacqueline Silva, Moura, Tuane Carolina Ferreira, da Silva Graça Amoras, Ednelza, Machado, Luiz Fernando Almeida, Guerreiro, João Farias, Vallinoto, Antonio Carlos Rosário, Queiroz, Maria Alice Freitas, Ishak, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697288/
https://www.ncbi.nlm.nih.gov/pubmed/36423182
http://dx.doi.org/10.3390/v14112573
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author de Souza, Ranilda Gama
Lima, Sandra Souza
Pinto, Andresa Corrêa
Souza, Jacqueline Silva
Moura, Tuane Carolina Ferreira
da Silva Graça Amoras, Ednelza
Machado, Luiz Fernando Almeida
Guerreiro, João Farias
Vallinoto, Antonio Carlos Rosário
Queiroz, Maria Alice Freitas
Ishak, Ricardo
author_facet de Souza, Ranilda Gama
Lima, Sandra Souza
Pinto, Andresa Corrêa
Souza, Jacqueline Silva
Moura, Tuane Carolina Ferreira
da Silva Graça Amoras, Ednelza
Machado, Luiz Fernando Almeida
Guerreiro, João Farias
Vallinoto, Antonio Carlos Rosário
Queiroz, Maria Alice Freitas
Ishak, Ricardo
author_sort de Souza, Ranilda Gama
collection PubMed
description Antiretroviral therapy (ART) improves the quality of life of people living with HIV-1 (PLHIV) and reduces the mortality rate, but some individuals may develop metabolic abnormalities. This study evaluated changes in the nutritional status and biochemistry of PLHIV on antiretroviral therapy in a cohort that had not previously received ART and to follow up these individuals for 24 months after starting treatment. The initial cohort consisted of 110 individuals and ended with 42 people, assessed by a physical examination. A biochemical assay was performed using the colorimetric enzyme reaction technique, the proviral load was detected by qPCR and the quantification of the CD4/CD8 T lymphocytes was conducted by flow cytometry. PLHIV had increased levels of total cholesterol, LDL, triglycerides, ALT, urea and creatinine after 24 months of ART use (p < 0.05). In the assessment of the nutritional status, PLHIV had increased measures of Triciptal Skinfold, body mass index and arm circumference after the use of ART (p < 0.05). The viral load levels decreased and the CD4 levels increased after 24 months of ART use (p < 0.05). The change in the nutritional status in PLHIV on antiretroviral therapy seems to be a slow process, occurring in the long term, therefore, there is the need for a constant evaluation of these people to identify patients who need a nutritional intervention.
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spelling pubmed-96972882022-11-26 Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy de Souza, Ranilda Gama Lima, Sandra Souza Pinto, Andresa Corrêa Souza, Jacqueline Silva Moura, Tuane Carolina Ferreira da Silva Graça Amoras, Ednelza Machado, Luiz Fernando Almeida Guerreiro, João Farias Vallinoto, Antonio Carlos Rosário Queiroz, Maria Alice Freitas Ishak, Ricardo Viruses Article Antiretroviral therapy (ART) improves the quality of life of people living with HIV-1 (PLHIV) and reduces the mortality rate, but some individuals may develop metabolic abnormalities. This study evaluated changes in the nutritional status and biochemistry of PLHIV on antiretroviral therapy in a cohort that had not previously received ART and to follow up these individuals for 24 months after starting treatment. The initial cohort consisted of 110 individuals and ended with 42 people, assessed by a physical examination. A biochemical assay was performed using the colorimetric enzyme reaction technique, the proviral load was detected by qPCR and the quantification of the CD4/CD8 T lymphocytes was conducted by flow cytometry. PLHIV had increased levels of total cholesterol, LDL, triglycerides, ALT, urea and creatinine after 24 months of ART use (p < 0.05). In the assessment of the nutritional status, PLHIV had increased measures of Triciptal Skinfold, body mass index and arm circumference after the use of ART (p < 0.05). The viral load levels decreased and the CD4 levels increased after 24 months of ART use (p < 0.05). The change in the nutritional status in PLHIV on antiretroviral therapy seems to be a slow process, occurring in the long term, therefore, there is the need for a constant evaluation of these people to identify patients who need a nutritional intervention. MDPI 2022-11-20 /pmc/articles/PMC9697288/ /pubmed/36423182 http://dx.doi.org/10.3390/v14112573 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Souza, Ranilda Gama
Lima, Sandra Souza
Pinto, Andresa Corrêa
Souza, Jacqueline Silva
Moura, Tuane Carolina Ferreira
da Silva Graça Amoras, Ednelza
Machado, Luiz Fernando Almeida
Guerreiro, João Farias
Vallinoto, Antonio Carlos Rosário
Queiroz, Maria Alice Freitas
Ishak, Ricardo
Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title_full Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title_fullStr Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title_full_unstemmed Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title_short Change in Nutritional and Biochemical Status in People Living with HIV-1 on Antiretroviral Therapy
title_sort change in nutritional and biochemical status in people living with hiv-1 on antiretroviral therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697288/
https://www.ncbi.nlm.nih.gov/pubmed/36423182
http://dx.doi.org/10.3390/v14112573
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