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Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes

This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery...

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Detalles Bibliográficos
Autores principales: Fazliana, Mansor, Nor Hanipah, Zubaidah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697340/
https://www.ncbi.nlm.nih.gov/pubmed/36422274
http://dx.doi.org/10.3390/metabo12111134
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author Fazliana, Mansor
Nor Hanipah, Zubaidah
author_facet Fazliana, Mansor
Nor Hanipah, Zubaidah
author_sort Fazliana, Mansor
collection PubMed
description This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk.
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spelling pubmed-96973402022-11-26 Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes Fazliana, Mansor Nor Hanipah, Zubaidah Metabolites Review This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. MDPI 2022-11-17 /pmc/articles/PMC9697340/ /pubmed/36422274 http://dx.doi.org/10.3390/metabo12111134 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fazliana, Mansor
Nor Hanipah, Zubaidah
Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title_full Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title_fullStr Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title_full_unstemmed Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title_short Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
title_sort mechanisms and outcomes of metabolic surgery in type 2 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697340/
https://www.ncbi.nlm.nih.gov/pubmed/36422274
http://dx.doi.org/10.3390/metabo12111134
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