Cargando…
Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697340/ https://www.ncbi.nlm.nih.gov/pubmed/36422274 http://dx.doi.org/10.3390/metabo12111134 |
_version_ | 1784838537930080256 |
---|---|
author | Fazliana, Mansor Nor Hanipah, Zubaidah |
author_facet | Fazliana, Mansor Nor Hanipah, Zubaidah |
author_sort | Fazliana, Mansor |
collection | PubMed |
description | This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. |
format | Online Article Text |
id | pubmed-9697340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96973402022-11-26 Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes Fazliana, Mansor Nor Hanipah, Zubaidah Metabolites Review This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. MDPI 2022-11-17 /pmc/articles/PMC9697340/ /pubmed/36422274 http://dx.doi.org/10.3390/metabo12111134 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fazliana, Mansor Nor Hanipah, Zubaidah Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title_full | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title_fullStr | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title_full_unstemmed | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title_short | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
title_sort | mechanisms and outcomes of metabolic surgery in type 2 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697340/ https://www.ncbi.nlm.nih.gov/pubmed/36422274 http://dx.doi.org/10.3390/metabo12111134 |
work_keys_str_mv | AT fazlianamansor mechanismsandoutcomesofmetabolicsurgeryintype2diabetes AT norhanipahzubaidah mechanismsandoutcomesofmetabolicsurgeryintype2diabetes |