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Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders

Puberty is a critical period of development marked by the maturation of the central nervous system, immune system, and hypothalamic–pituitary–adrenal axis. Due to the maturation of these fundamental systems, this is a period of development that is particularly sensitive to stressors, increasing susc...

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Autores principales: Esposito, Pasquale, Ismail, Nafissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697368/
https://www.ncbi.nlm.nih.gov/pubmed/36363755
http://dx.doi.org/10.3390/microorganisms10112163
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author Esposito, Pasquale
Ismail, Nafissa
author_facet Esposito, Pasquale
Ismail, Nafissa
author_sort Esposito, Pasquale
collection PubMed
description Puberty is a critical period of development marked by the maturation of the central nervous system, immune system, and hypothalamic–pituitary–adrenal axis. Due to the maturation of these fundamental systems, this is a period of development that is particularly sensitive to stressors, increasing susceptibility to neurodevelopmental and neurodegenerative disorders later in life. The gut microbiome plays a critical role in the regulation of stress and immune responses, and gut dysbiosis has been implicated in the development of neurodevelopmental and neurodegenerative disorders. The purpose of this review is to summarize the current knowledge about puberty, neurodegeneration, and the gut microbiome. We also examine the consequences of pubertal exposure to stress and gut dysbiosis on the development of neurodevelopmental and neurodegenerative disorders. Understanding how alterations to the gut microbiome, particularly during critical periods of development (i.e., puberty), influence the pathogenesis of these disorders may allow for the development of therapeutic strategies to prevent them.
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spelling pubmed-96973682022-11-26 Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders Esposito, Pasquale Ismail, Nafissa Microorganisms Review Puberty is a critical period of development marked by the maturation of the central nervous system, immune system, and hypothalamic–pituitary–adrenal axis. Due to the maturation of these fundamental systems, this is a period of development that is particularly sensitive to stressors, increasing susceptibility to neurodevelopmental and neurodegenerative disorders later in life. The gut microbiome plays a critical role in the regulation of stress and immune responses, and gut dysbiosis has been implicated in the development of neurodevelopmental and neurodegenerative disorders. The purpose of this review is to summarize the current knowledge about puberty, neurodegeneration, and the gut microbiome. We also examine the consequences of pubertal exposure to stress and gut dysbiosis on the development of neurodevelopmental and neurodegenerative disorders. Understanding how alterations to the gut microbiome, particularly during critical periods of development (i.e., puberty), influence the pathogenesis of these disorders may allow for the development of therapeutic strategies to prevent them. MDPI 2022-10-31 /pmc/articles/PMC9697368/ /pubmed/36363755 http://dx.doi.org/10.3390/microorganisms10112163 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Esposito, Pasquale
Ismail, Nafissa
Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title_full Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title_fullStr Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title_full_unstemmed Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title_short Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders
title_sort linking puberty and the gut microbiome to the pathogenesis of neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697368/
https://www.ncbi.nlm.nih.gov/pubmed/36363755
http://dx.doi.org/10.3390/microorganisms10112163
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