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Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability

Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines. mRNA-LNP formulations have been indicated to require strict control, including maintenance at fairly low temperatures during th...

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Detalles Bibliográficos
Autores principales:	Kamiya, Mariko, Matsumoto, Makoto, Yamashita, Kazuma, Izumi, Tatsunori, Kawaguchi, Maho, Mizukami, Shusaku, Tsurumaru, Masako, Mukai, Hidefumi, Kawakami, Shigeru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697436/ https://www.ncbi.nlm.nih.gov/pubmed/36365175 http://dx.doi.org/10.3390/pharmaceutics14112357

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