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Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications

Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest...

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Autores principales: Nakiou, Eirini A., Lazaridou, Maria, Pouroutzidou, Georgia K., Michopoulou, Anna, Tsamesidis, Ioannis, Liverani, Liliana, Arango-Ospina, Marcela, Beketova, Anastasia, Boccaccini, Aldo R., Kontonasaki, Eleana, Bikiaris, Dimitrios N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697483/
https://www.ncbi.nlm.nih.gov/pubmed/36433155
http://dx.doi.org/10.3390/polym14225028
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author Nakiou, Eirini A.
Lazaridou, Maria
Pouroutzidou, Georgia K.
Michopoulou, Anna
Tsamesidis, Ioannis
Liverani, Liliana
Arango-Ospina, Marcela
Beketova, Anastasia
Boccaccini, Aldo R.
Kontonasaki, Eleana
Bikiaris, Dimitrios N.
author_facet Nakiou, Eirini A.
Lazaridou, Maria
Pouroutzidou, Georgia K.
Michopoulou, Anna
Tsamesidis, Ioannis
Liverani, Liliana
Arango-Ospina, Marcela
Beketova, Anastasia
Boccaccini, Aldo R.
Kontonasaki, Eleana
Bikiaris, Dimitrios N.
author_sort Nakiou, Eirini A.
collection PubMed
description Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest. Succinic acid and bio-based diacids similar to glycerol are regarded as safe materials according to the US Food and Drug Administration (FDA). Bioactive glass scaffolds utilized in bone tissue engineering are relatively brittle materials. However, their mechanical properties can be improved by using polymer coatings that can further control their degradation rate, tailor their biocompatibility and enhance their performance. The purpose of this study is to explore a new biopolyester poly(glycerol succinate) (PGSuc) reinforced with mesoporous bioactive nanoparticles (MSNs) as a novel coating material to produce hybrid scaffolds for bone tissue engineering. Methods: Bioactive glass scaffolds were coated with neat PGSuc, PGSuc loaded with dexamethasone sodium phosphate (DexSP) and PGSuc loaded with DexSP-laden MSNs. The physicochemical, mechanical and biological properties of the scaffolds were also evaluated. Results: Preliminary data are provided showing that polymer coatings with and without MSNs improved the physicochemical properties of the 1393 bioactive glass scaffolds and increased the ALP activity and alizarin red staining, suggesting osteogenic differentiation potential when cultured with adipose-derived mesenchymal stem cells. Conclusions: PGSuc with incorporated MSNs coated onto 1393 bioactive glass scaffolds could be promising candidates in bone tissue engineering applications.
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spelling pubmed-96974832022-11-26 Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications Nakiou, Eirini A. Lazaridou, Maria Pouroutzidou, Georgia K. Michopoulou, Anna Tsamesidis, Ioannis Liverani, Liliana Arango-Ospina, Marcela Beketova, Anastasia Boccaccini, Aldo R. Kontonasaki, Eleana Bikiaris, Dimitrios N. Polymers (Basel) Article Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest. Succinic acid and bio-based diacids similar to glycerol are regarded as safe materials according to the US Food and Drug Administration (FDA). Bioactive glass scaffolds utilized in bone tissue engineering are relatively brittle materials. However, their mechanical properties can be improved by using polymer coatings that can further control their degradation rate, tailor their biocompatibility and enhance their performance. The purpose of this study is to explore a new biopolyester poly(glycerol succinate) (PGSuc) reinforced with mesoporous bioactive nanoparticles (MSNs) as a novel coating material to produce hybrid scaffolds for bone tissue engineering. Methods: Bioactive glass scaffolds were coated with neat PGSuc, PGSuc loaded with dexamethasone sodium phosphate (DexSP) and PGSuc loaded with DexSP-laden MSNs. The physicochemical, mechanical and biological properties of the scaffolds were also evaluated. Results: Preliminary data are provided showing that polymer coatings with and without MSNs improved the physicochemical properties of the 1393 bioactive glass scaffolds and increased the ALP activity and alizarin red staining, suggesting osteogenic differentiation potential when cultured with adipose-derived mesenchymal stem cells. Conclusions: PGSuc with incorporated MSNs coated onto 1393 bioactive glass scaffolds could be promising candidates in bone tissue engineering applications. MDPI 2022-11-19 /pmc/articles/PMC9697483/ /pubmed/36433155 http://dx.doi.org/10.3390/polym14225028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nakiou, Eirini A.
Lazaridou, Maria
Pouroutzidou, Georgia K.
Michopoulou, Anna
Tsamesidis, Ioannis
Liverani, Liliana
Arango-Ospina, Marcela
Beketova, Anastasia
Boccaccini, Aldo R.
Kontonasaki, Eleana
Bikiaris, Dimitrios N.
Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title_full Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title_fullStr Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title_full_unstemmed Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title_short Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications
title_sort poly(glycerol succinate) as coating material for 1393 bioactive glass porous scaffolds for tissue engineering applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697483/
https://www.ncbi.nlm.nih.gov/pubmed/36433155
http://dx.doi.org/10.3390/polym14225028
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