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Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance
In this pilot clinical trial, we evaluated rates of residual replication in persons without lamivudine resistance-associated mutations in proviral DNA population sequencing who switched to dolutegravir plus lamivudine. After 144 weeks, there was no signal of changes in residual viremia based on qual...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697602/ https://www.ncbi.nlm.nih.gov/pubmed/36447613 http://dx.doi.org/10.1093/ofid/ofac610 |
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| author | De Miguel Buckley, Rosa Rial-Crestelo, David Montejano, Rocío Pinto, Adriana Jimenez-Gonzalez, María Lagarde, Maria Esteban-Cantos, Andrés Aranguren-Rivas, Paula Cadiñanos, Julen Bisbal, Otilia Castro, Juan Miguel Santacreu-Guerrero, Mireia Bermejo-Plaza, Laura Moreno, Victoria Hernando, Asunción Martín-Carbonero, Luz Rubio, Rafael Delgado, Rafael Arribas, José Ramón Pulido, Federico |
| author_facet | De Miguel Buckley, Rosa Rial-Crestelo, David Montejano, Rocío Pinto, Adriana Jimenez-Gonzalez, María Lagarde, Maria Esteban-Cantos, Andrés Aranguren-Rivas, Paula Cadiñanos, Julen Bisbal, Otilia Castro, Juan Miguel Santacreu-Guerrero, Mireia Bermejo-Plaza, Laura Moreno, Victoria Hernando, Asunción Martín-Carbonero, Luz Rubio, Rafael Delgado, Rafael Arribas, José Ramón Pulido, Federico |
| author_sort | De Miguel Buckley, Rosa |
| collection | PubMed |
| description | In this pilot clinical trial, we evaluated rates of residual replication in persons without lamivudine resistance-associated mutations in proviral DNA population sequencing who switched to dolutegravir plus lamivudine. After 144 weeks, there was no signal of changes in residual viremia based on qualitative detection methods, irrespective of past lamivudine resistance. Clinical Trials Registration. NCT03539224. |
| format | Online Article Text |
| id | pubmed-9697602 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96976022022-11-28 Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance De Miguel Buckley, Rosa Rial-Crestelo, David Montejano, Rocío Pinto, Adriana Jimenez-Gonzalez, María Lagarde, Maria Esteban-Cantos, Andrés Aranguren-Rivas, Paula Cadiñanos, Julen Bisbal, Otilia Castro, Juan Miguel Santacreu-Guerrero, Mireia Bermejo-Plaza, Laura Moreno, Victoria Hernando, Asunción Martín-Carbonero, Luz Rubio, Rafael Delgado, Rafael Arribas, José Ramón Pulido, Federico Open Forum Infect Dis Brief Report In this pilot clinical trial, we evaluated rates of residual replication in persons without lamivudine resistance-associated mutations in proviral DNA population sequencing who switched to dolutegravir plus lamivudine. After 144 weeks, there was no signal of changes in residual viremia based on qualitative detection methods, irrespective of past lamivudine resistance. Clinical Trials Registration. NCT03539224. Oxford University Press 2022-11-08 /pmc/articles/PMC9697602/ /pubmed/36447613 http://dx.doi.org/10.1093/ofid/ofac610 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report De Miguel Buckley, Rosa Rial-Crestelo, David Montejano, Rocío Pinto, Adriana Jimenez-Gonzalez, María Lagarde, Maria Esteban-Cantos, Andrés Aranguren-Rivas, Paula Cadiñanos, Julen Bisbal, Otilia Castro, Juan Miguel Santacreu-Guerrero, Mireia Bermejo-Plaza, Laura Moreno, Victoria Hernando, Asunción Martín-Carbonero, Luz Rubio, Rafael Delgado, Rafael Arribas, José Ramón Pulido, Federico Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title | Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title_full | Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title_fullStr | Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title_full_unstemmed | Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title_short | Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance |
| title_sort | long-term evaluation of residual viremia in a clinical trial of dolutegravir plus lamivudine as maintenance treatment for participants with and without prior lamivudine resistance |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697602/ https://www.ncbi.nlm.nih.gov/pubmed/36447613 http://dx.doi.org/10.1093/ofid/ofac610 |
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