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Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination

We report an unusual case of nephrotic syndrome and multiple venous thromboembolism (VTE) four days after BNT162b2 injection. The patient presented with a three-day history of foamy urine and one-day history of right leg swelling. The investigation showed 9.5 g of 24 hr urine protein, hypoalbuminemi...

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Autores principales: Thammathiwat, Theerachai, Banjongjit, Athiphat, Chumnumsiriwath, Piyatida, Chompuk, Laor, Sripariwuth, Apichaya, Pongcharoen, Sutatip, Kanjanabuch, Talerngsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697681/
https://www.ncbi.nlm.nih.gov/pubmed/36366397
http://dx.doi.org/10.3390/vaccines10111888
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author Thammathiwat, Theerachai
Banjongjit, Athiphat
Chumnumsiriwath, Piyatida
Chompuk, Laor
Sripariwuth, Apichaya
Pongcharoen, Sutatip
Kanjanabuch, Talerngsak
author_facet Thammathiwat, Theerachai
Banjongjit, Athiphat
Chumnumsiriwath, Piyatida
Chompuk, Laor
Sripariwuth, Apichaya
Pongcharoen, Sutatip
Kanjanabuch, Talerngsak
author_sort Thammathiwat, Theerachai
collection PubMed
description We report an unusual case of nephrotic syndrome and multiple venous thromboembolism (VTE) four days after BNT162b2 injection. The patient presented with a three-day history of foamy urine and one-day history of right leg swelling. The investigation showed 9.5 g of 24 hr urine protein, hypoalbuminemia (2.6 gm/dL), and hypercholesterolemia (320 mg/dL). The duplex ultrasonography revealed VTE of the right lower extremity veins (common femoral vein, saphenous vein, and popliteal vein). Computed tomography (CT) showed thrombosis of the infrarenal inferior vena cava (IVC) extending to both iliac veins and acute pulmonary embolism. Kidney biopsy was performed. The diagnosis of minimal change disease was made. The patient received anticoagulation without steroid or immunosuppressive medications. The nephrosis was spontaneously resolved in 20 days; thus, it strongly suggested the diagnosis of vaccine-induced minimal change nephropathy. Reports of kidney adverse events and clinical characteristics are further needed in the circumstances of worldwide SARS-CoV-2 vaccine usage.
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spelling pubmed-96976812022-11-26 Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination Thammathiwat, Theerachai Banjongjit, Athiphat Chumnumsiriwath, Piyatida Chompuk, Laor Sripariwuth, Apichaya Pongcharoen, Sutatip Kanjanabuch, Talerngsak Vaccines (Basel) Case Report We report an unusual case of nephrotic syndrome and multiple venous thromboembolism (VTE) four days after BNT162b2 injection. The patient presented with a three-day history of foamy urine and one-day history of right leg swelling. The investigation showed 9.5 g of 24 hr urine protein, hypoalbuminemia (2.6 gm/dL), and hypercholesterolemia (320 mg/dL). The duplex ultrasonography revealed VTE of the right lower extremity veins (common femoral vein, saphenous vein, and popliteal vein). Computed tomography (CT) showed thrombosis of the infrarenal inferior vena cava (IVC) extending to both iliac veins and acute pulmonary embolism. Kidney biopsy was performed. The diagnosis of minimal change disease was made. The patient received anticoagulation without steroid or immunosuppressive medications. The nephrosis was spontaneously resolved in 20 days; thus, it strongly suggested the diagnosis of vaccine-induced minimal change nephropathy. Reports of kidney adverse events and clinical characteristics are further needed in the circumstances of worldwide SARS-CoV-2 vaccine usage. MDPI 2022-11-09 /pmc/articles/PMC9697681/ /pubmed/36366397 http://dx.doi.org/10.3390/vaccines10111888 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Thammathiwat, Theerachai
Banjongjit, Athiphat
Chumnumsiriwath, Piyatida
Chompuk, Laor
Sripariwuth, Apichaya
Pongcharoen, Sutatip
Kanjanabuch, Talerngsak
Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title_full Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title_fullStr Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title_full_unstemmed Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title_short Multiple Venous and Pulmonary Artery Thrombosis as the Presenting Features of Spontaneously Reversible Nephrotic Syndrome after Exposure to SARS-CoV-2 Virus (Pfizer/BioNTech BNT162b2) Vaccination
title_sort multiple venous and pulmonary artery thrombosis as the presenting features of spontaneously reversible nephrotic syndrome after exposure to sars-cov-2 virus (pfizer/biontech bnt162b2) vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697681/
https://www.ncbi.nlm.nih.gov/pubmed/36366397
http://dx.doi.org/10.3390/vaccines10111888
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