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Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022

The quantification and molecular characterization of the AdV genome in urban wastewater samples (WWSs) collected weekly at a wastewater treatment plant (WWTP) in Milan from 1 January 2021 (week 2021-01) to 1 May 2022 (week 2022-17) were performed. The concentration of the AdV genome was graphically...

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Autores principales: Pellegrinelli, Laura, Uceda Renteria, Sara Colonia, Ceriotti, Ferruccio, Ammoni, Emanuela, Galli, Cristina, Seiti, Arlinda, Castiglioni, Sara, Cereda, Danilo, Binda, Sandro, Pariani, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697775/
https://www.ncbi.nlm.nih.gov/pubmed/36366449
http://dx.doi.org/10.3390/v14112351
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author Pellegrinelli, Laura
Uceda Renteria, Sara Colonia
Ceriotti, Ferruccio
Ammoni, Emanuela
Galli, Cristina
Seiti, Arlinda
Castiglioni, Sara
Cereda, Danilo
Binda, Sandro
Pariani, Elena
author_facet Pellegrinelli, Laura
Uceda Renteria, Sara Colonia
Ceriotti, Ferruccio
Ammoni, Emanuela
Galli, Cristina
Seiti, Arlinda
Castiglioni, Sara
Cereda, Danilo
Binda, Sandro
Pariani, Elena
author_sort Pellegrinelli, Laura
collection PubMed
description The quantification and molecular characterization of the AdV genome in urban wastewater samples (WWSs) collected weekly at a wastewater treatment plant (WWTP) in Milan from 1 January 2021 (week 2021-01) to 1 May 2022 (week 2022-17) were performed. The concentration of the AdV genome was graphically compared with the AdV positive rate observed in the respiratory/gastrointestinal specimens from individuals hospitalized with acute respiratory/gastrointestinal infections collected from one of the major hospitals in Milan in the same time series. An increase in the AdV circulation in WWSs was seen from November 2021, peaking in March 2022 and overlapped with an increase in the AdV positive rate in respiratory/fecal samples from individuals hospitalized with acute respiratory/gastrointestinal infections. The molecular characterization of the hexon hypervariable region of loop 1 of AdV revealed the presence of the species F type 41 in WWSs collected from February 2022 to April 2022. The wastewater surveillance of AdV can provide crucial epidemiological characteristics regarding AdV, particularly where no clinical surveillance is ongoing. The increase in the AdV circulation in Milan both in WWSs and clinical samples temporally overlapped with the outbreak of severe acute pediatric hepatitis observed in Europe and needs to be better investigated.
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spelling pubmed-96977752022-11-26 Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022 Pellegrinelli, Laura Uceda Renteria, Sara Colonia Ceriotti, Ferruccio Ammoni, Emanuela Galli, Cristina Seiti, Arlinda Castiglioni, Sara Cereda, Danilo Binda, Sandro Pariani, Elena Viruses Communication The quantification and molecular characterization of the AdV genome in urban wastewater samples (WWSs) collected weekly at a wastewater treatment plant (WWTP) in Milan from 1 January 2021 (week 2021-01) to 1 May 2022 (week 2022-17) were performed. The concentration of the AdV genome was graphically compared with the AdV positive rate observed in the respiratory/gastrointestinal specimens from individuals hospitalized with acute respiratory/gastrointestinal infections collected from one of the major hospitals in Milan in the same time series. An increase in the AdV circulation in WWSs was seen from November 2021, peaking in March 2022 and overlapped with an increase in the AdV positive rate in respiratory/fecal samples from individuals hospitalized with acute respiratory/gastrointestinal infections. The molecular characterization of the hexon hypervariable region of loop 1 of AdV revealed the presence of the species F type 41 in WWSs collected from February 2022 to April 2022. The wastewater surveillance of AdV can provide crucial epidemiological characteristics regarding AdV, particularly where no clinical surveillance is ongoing. The increase in the AdV circulation in Milan both in WWSs and clinical samples temporally overlapped with the outbreak of severe acute pediatric hepatitis observed in Europe and needs to be better investigated. MDPI 2022-10-26 /pmc/articles/PMC9697775/ /pubmed/36366449 http://dx.doi.org/10.3390/v14112351 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pellegrinelli, Laura
Uceda Renteria, Sara Colonia
Ceriotti, Ferruccio
Ammoni, Emanuela
Galli, Cristina
Seiti, Arlinda
Castiglioni, Sara
Cereda, Danilo
Binda, Sandro
Pariani, Elena
Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title_full Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title_fullStr Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title_full_unstemmed Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title_short Wastewater Surveillance Captured an Increase in Adenovirus Circulation in Milan (Italy) during the First Quarter of 2022
title_sort wastewater surveillance captured an increase in adenovirus circulation in milan (italy) during the first quarter of 2022
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697775/
https://www.ncbi.nlm.nih.gov/pubmed/36366449
http://dx.doi.org/10.3390/v14112351
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