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Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?

Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalizati...

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Autores principales: Hegelund, Maria H., Ryrsø, Camilla K., Ritz, Christian, Dungu, Arnold M., Sejdic, Adin, Jensen, Andreas V., Hansen, Nikita M., Mølgaard, Christian, Krogh-Madsen, Rikke, Lindegaard, Birgitte, Faurholt-Jepsen, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697837/
https://www.ncbi.nlm.nih.gov/pubmed/36432592
http://dx.doi.org/10.3390/nu14224906
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author Hegelund, Maria H.
Ryrsø, Camilla K.
Ritz, Christian
Dungu, Arnold M.
Sejdic, Adin
Jensen, Andreas V.
Hansen, Nikita M.
Mølgaard, Christian
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Faurholt-Jepsen, Daniel
author_facet Hegelund, Maria H.
Ryrsø, Camilla K.
Ritz, Christian
Dungu, Arnold M.
Sejdic, Adin
Jensen, Andreas V.
Hansen, Nikita M.
Mølgaard, Christian
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Faurholt-Jepsen, Daniel
author_sort Hegelund, Maria H.
collection PubMed
description Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.
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spelling pubmed-96978372022-11-26 Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia? Hegelund, Maria H. Ryrsø, Camilla K. Ritz, Christian Dungu, Arnold M. Sejdic, Adin Jensen, Andreas V. Hansen, Nikita M. Mølgaard, Christian Krogh-Madsen, Rikke Lindegaard, Birgitte Faurholt-Jepsen, Daniel Nutrients Article Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival. MDPI 2022-11-19 /pmc/articles/PMC9697837/ /pubmed/36432592 http://dx.doi.org/10.3390/nu14224906 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hegelund, Maria H.
Ryrsø, Camilla K.
Ritz, Christian
Dungu, Arnold M.
Sejdic, Adin
Jensen, Andreas V.
Hansen, Nikita M.
Mølgaard, Christian
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Faurholt-Jepsen, Daniel
Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title_full Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title_fullStr Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title_full_unstemmed Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title_short Are Undernutrition and Obesity Associated with Post-Discharge Mortality and Re-Hospitalization after Hospitalization with Community-Acquired Pneumonia?
title_sort are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697837/
https://www.ncbi.nlm.nih.gov/pubmed/36432592
http://dx.doi.org/10.3390/nu14224906
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