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Surface Modification with Particles Coated or Made of Polymer Multilayers

The coating of particles or decomposable cores with polyelectrolytes via Layer-by-Layer (LbL) assembly creates free-standing LbL-coated functional particles. Due to the numerous functions that their polymers can bestow, the particles are preferentially selected for a plethora of applications, includ...

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Autores principales: Kotoulas, Konstantinos T., Campbell, Jack, Skirtach, Andre G., Volodkin, Dmitry, Vikulina, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697854/
https://www.ncbi.nlm.nih.gov/pubmed/36432674
http://dx.doi.org/10.3390/pharmaceutics14112483
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author Kotoulas, Konstantinos T.
Campbell, Jack
Skirtach, Andre G.
Volodkin, Dmitry
Vikulina, Anna
author_facet Kotoulas, Konstantinos T.
Campbell, Jack
Skirtach, Andre G.
Volodkin, Dmitry
Vikulina, Anna
author_sort Kotoulas, Konstantinos T.
collection PubMed
description The coating of particles or decomposable cores with polyelectrolytes via Layer-by-Layer (LbL) assembly creates free-standing LbL-coated functional particles. Due to the numerous functions that their polymers can bestow, the particles are preferentially selected for a plethora of applications, including, but not limited to coatings, cargo-carriers, drug delivery vehicles and fabric enhancements. The number of publications discussing the fabrication and usage of LbL-assembled particles has consistently increased over the last vicennial. However, past literature fails to either mention or expand upon how these LbL-assembled particles immobilize on to a solid surface. This review evaluates examples of LbL-assembled particles that have been immobilized on to solid surfaces. To aid in the formulation of a mechanism for immobilization, this review examines which forces and factors influence immobilization, and how the latter can be confirmed. The predominant forces in the immobilization of the particles studied here are the Coulombic, capillary, and adhesive forces; hydrogen bonding as well as van der Waal’s and hydrophobic interactions are also considered. These are heavily dependent on the factors that influenced immobilization, such as the particle morphology and surface charge. The shape of the LbL particle is related to the particle core, whereas the charge was dependant on the outermost polyelectrolyte in the multilayer coating. The polyelectrolytes also determine the type of bonding that a particle can form with a solid surface. These can be via either physical (non-covalent) or chemical (covalent) bonds; the latter enforcing a stronger immobilization. This review proposes a fundamental theory for immobilization pathways and can be used to support future research in the field of surface patterning and for the general modification of solid surfaces with polymer-based nano- and micro-sized polymer structures.
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spelling pubmed-96978542022-11-26 Surface Modification with Particles Coated or Made of Polymer Multilayers Kotoulas, Konstantinos T. Campbell, Jack Skirtach, Andre G. Volodkin, Dmitry Vikulina, Anna Pharmaceutics Review The coating of particles or decomposable cores with polyelectrolytes via Layer-by-Layer (LbL) assembly creates free-standing LbL-coated functional particles. Due to the numerous functions that their polymers can bestow, the particles are preferentially selected for a plethora of applications, including, but not limited to coatings, cargo-carriers, drug delivery vehicles and fabric enhancements. The number of publications discussing the fabrication and usage of LbL-assembled particles has consistently increased over the last vicennial. However, past literature fails to either mention or expand upon how these LbL-assembled particles immobilize on to a solid surface. This review evaluates examples of LbL-assembled particles that have been immobilized on to solid surfaces. To aid in the formulation of a mechanism for immobilization, this review examines which forces and factors influence immobilization, and how the latter can be confirmed. The predominant forces in the immobilization of the particles studied here are the Coulombic, capillary, and adhesive forces; hydrogen bonding as well as van der Waal’s and hydrophobic interactions are also considered. These are heavily dependent on the factors that influenced immobilization, such as the particle morphology and surface charge. The shape of the LbL particle is related to the particle core, whereas the charge was dependant on the outermost polyelectrolyte in the multilayer coating. The polyelectrolytes also determine the type of bonding that a particle can form with a solid surface. These can be via either physical (non-covalent) or chemical (covalent) bonds; the latter enforcing a stronger immobilization. This review proposes a fundamental theory for immobilization pathways and can be used to support future research in the field of surface patterning and for the general modification of solid surfaces with polymer-based nano- and micro-sized polymer structures. MDPI 2022-11-16 /pmc/articles/PMC9697854/ /pubmed/36432674 http://dx.doi.org/10.3390/pharmaceutics14112483 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kotoulas, Konstantinos T.
Campbell, Jack
Skirtach, Andre G.
Volodkin, Dmitry
Vikulina, Anna
Surface Modification with Particles Coated or Made of Polymer Multilayers
title Surface Modification with Particles Coated or Made of Polymer Multilayers
title_full Surface Modification with Particles Coated or Made of Polymer Multilayers
title_fullStr Surface Modification with Particles Coated or Made of Polymer Multilayers
title_full_unstemmed Surface Modification with Particles Coated or Made of Polymer Multilayers
title_short Surface Modification with Particles Coated or Made of Polymer Multilayers
title_sort surface modification with particles coated or made of polymer multilayers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697854/
https://www.ncbi.nlm.nih.gov/pubmed/36432674
http://dx.doi.org/10.3390/pharmaceutics14112483
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