A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides

The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no comprehensive review dedicated to the synthesis and chemi...

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Autor principal: Mphahlele, Malose J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697966/
https://www.ncbi.nlm.nih.gov/pubmed/36432084
http://dx.doi.org/10.3390/molecules27227985
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author Mphahlele, Malose J.
author_facet Mphahlele, Malose J.
author_sort Mphahlele, Malose J.
collection PubMed
description The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no comprehensive review dedicated to the synthesis and chemical transformation of these biologically relevant azaaromatic oxides. This review aims to provide an up-to-date record of the synthesis of quinazoline 3-oxides and their chemical transformation. It is hoped that this information will help medicinal chemistry researchers to design and synthesize new derivatives or analogues to treat various diseases.
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spelling pubmed-96979662022-11-26 A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides Mphahlele, Malose J. Molecules Review The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no comprehensive review dedicated to the synthesis and chemical transformation of these biologically relevant azaaromatic oxides. This review aims to provide an up-to-date record of the synthesis of quinazoline 3-oxides and their chemical transformation. It is hoped that this information will help medicinal chemistry researchers to design and synthesize new derivatives or analogues to treat various diseases. MDPI 2022-11-17 /pmc/articles/PMC9697966/ /pubmed/36432084 http://dx.doi.org/10.3390/molecules27227985 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mphahlele, Malose J.
A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title_full A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title_fullStr A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title_full_unstemmed A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title_short A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
title_sort review on the synthesis and chemical transformation of quinazoline 3-oxides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697966/
https://www.ncbi.nlm.nih.gov/pubmed/36432084
http://dx.doi.org/10.3390/molecules27227985
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