sFlt-1 in Chronic Kidney Disease: Friend or Foe?

Placental growth factor (PlGF) and its receptor, fms-like tyrosine kinase-1 (Flt-1), are important regulators involved in angiogenesis, atherogenesis, and inflammation. This review article focuses on the function of PlGF/Flt-1 signaling and its regulation by soluble Flt-1 (sFlt-1) in chronic kidney...

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Detalles Bibliográficos
Autores principales: Matsui, Masaru, Onoue, Kenji, Saito, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697971/
https://www.ncbi.nlm.nih.gov/pubmed/36430665
http://dx.doi.org/10.3390/ijms232214187
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author Matsui, Masaru
Onoue, Kenji
Saito, Yoshihiko
author_facet Matsui, Masaru
Onoue, Kenji
Saito, Yoshihiko
author_sort Matsui, Masaru
collection PubMed
description Placental growth factor (PlGF) and its receptor, fms-like tyrosine kinase-1 (Flt-1), are important regulators involved in angiogenesis, atherogenesis, and inflammation. This review article focuses on the function of PlGF/Flt-1 signaling and its regulation by soluble Flt-1 (sFlt-1) in chronic kidney disease (CKD). Elevation of circulating sFlt-1 and downregulation of sFlt-1 in the vascular endothelium by uremic toxins and oxidative stress both exacerbate heart failure and atherosclerosis. Circulating sFlt-1 is inconsistent with sFlt-1 synthesis, because levels of matrix-bound sFlt-1 are much higher than those of circulating sFlt-1, as verified by a heparin loading test, and are drastically reduced in CKD.
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spelling pubmed-96979712022-11-26 sFlt-1 in Chronic Kidney Disease: Friend or Foe? Matsui, Masaru Onoue, Kenji Saito, Yoshihiko Int J Mol Sci Review Placental growth factor (PlGF) and its receptor, fms-like tyrosine kinase-1 (Flt-1), are important regulators involved in angiogenesis, atherogenesis, and inflammation. This review article focuses on the function of PlGF/Flt-1 signaling and its regulation by soluble Flt-1 (sFlt-1) in chronic kidney disease (CKD). Elevation of circulating sFlt-1 and downregulation of sFlt-1 in the vascular endothelium by uremic toxins and oxidative stress both exacerbate heart failure and atherosclerosis. Circulating sFlt-1 is inconsistent with sFlt-1 synthesis, because levels of matrix-bound sFlt-1 are much higher than those of circulating sFlt-1, as verified by a heparin loading test, and are drastically reduced in CKD. MDPI 2022-11-16 /pmc/articles/PMC9697971/ /pubmed/36430665 http://dx.doi.org/10.3390/ijms232214187 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsui, Masaru
Onoue, Kenji
Saito, Yoshihiko
sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title_full sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title_fullStr sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title_full_unstemmed sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title_short sFlt-1 in Chronic Kidney Disease: Friend or Foe?
title_sort sflt-1 in chronic kidney disease: friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697971/
https://www.ncbi.nlm.nih.gov/pubmed/36430665
http://dx.doi.org/10.3390/ijms232214187
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