Cargando…

Giardia lamblia G6PD::6PGL Fused Protein Inhibitors Decrease Trophozoite Viability: A New Alternative against Giardiasis

Treatments to combat giardiasis have been reported to have several drawbacks, partly due to the drug resistance and toxicity of current antiparasitic agents. These constraints have prompted many researchers to investigate new drugs that act against protozoan parasites. Enzyme inhibition is an import...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morales-Luna, Laura, Hernández-Ochoa, Beatriz, Martínez-Rosas, Víctor, Navarrete-Vázquez, Gabriel, Ortega-Cuellar, Daniel, Rufino-González, Yadira, González-Valdez, Abigail, Arreguin-Espinosa, Roberto, Franco-Vásquez, Adrián Marcelo, Pérez de la Cruz, Verónica, Enríquez-Flores, Sergio, Martínez-Conde, Carlos, Canseco-Ávila, Luis Miguel, Gómez-Chávez, Fernando, Gómez-Manzo, Saúl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697976/ https://www.ncbi.nlm.nih.gov/pubmed/36430836 http://dx.doi.org/10.3390/ijms232214358

Ejemplares similares

Identification of the NADP(+) Structural Binding Site and Coenzyme Effect on the Fused G6PD::6PGL Protein from Giardia lamblia
por: Morales-Luna, Laura, et al.
Publicado: (2019)

Nitazoxanide Inhibits the Bifunctional Enzyme GlG6PD::6PGL of Giardia lamblia: Biochemical and In Silico Characterization of a New Druggable Target
por: Martínez-Rosas, Víctor, et al.
Publicado: (2023)

Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase from the Parasite Giardia lamblia. A Molecular and Biochemical Perspective of a Fused Enzyme
por: Morales-Luna, Laura, et al.
Publicado: (2021)

Biochemical Characterization and Structural Modeling of Fused Glucose-6-Phosphate Dehydrogenase-Phosphogluconolactonase from Giardia lamblia
por: Morales-Luna, Laura, et al.
Publicado: (2018)

Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis
por: Hernández-Ochoa, Beatriz, et al.
Publicado: (2022)

Kinetic and Molecular Docking Studies to Determine the Effect of Inhibitors on the Activity and Structure of Fused G6PD::6PGL Protein from Trichomonas vaginalis
por: Martínez-Rosas, Víctor, et al.
Publicado: (2022)

Characterizing the Fused TvG6PD::6PGL Protein from the Protozoan Trichomonas vaginalis, and Effects of the NADP(+) Molecule on Enzyme Stability
por: Morales-Luna, Laura, et al.
Publicado: (2020)

Activity of Thioallyl Compounds From Garlic Against Giardia duodenalis Trophozoites and in Experimental Giardiasis
por: Argüello-García, Raúl, et al.
Publicado: (2018)

A comparison of the Giardia lamblia trophozoite and cyst transcriptome using microarrays
por: Faghiri, Zahra, et al.
Publicado: (2011)

Stem-Loop RT-qPCR as an Efficient Tool for the Detection and Quantification of Small RNAs in Giardia lamblia
por: Marcial-Quino, Jaime, et al.
Publicado: (2016)

Experimental Verification of the Identity of Variant-Specific Surface Proteins in Giardia lamblia Trophozoites
por: Li, Wei, et al.
Publicado: (2013)

Effects of the extract and glycoalkaloids of Solanum lycocarpum St. Hill on Giardia lamblia trophozoites
por: Martins, Gilmarcio Z., et al.
Publicado: (2015)

Giardia lamblia miRNAs as a new diagnostic tool for human giardiasis
por: Meningher, Tal, et al.
Publicado: (2019)

In vitro activity of some natural honeys against Entamoeba histolytica and Giardia lamblia trophozoites
por: Mohammed, Seif Eldin A., et al.
Publicado: (2019)

RNAi-Mediated Specific Gene Silencing as a Tool for the Discovery of New Drug Targets in Giardia lamblia; Evaluation Using the NADH Oxidase Gene
por: Marcial-Quino, Jaime, et al.
Publicado: (2017)

Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential
por: Castillo-Villanueva, Adriana, et al.
Publicado: (2017)

Polyphenolic extract from Punica granatum peel causes cytoskeleton-related damage on Giardia lamblia trophozoites in vitro
por: Palomo-Ligas, Lissethe, et al.
Publicado: (2022)

Virtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phase
por: Juárez-Saldivar, Alfredo, et al.
Publicado: (2021)

Transfection With Plasmid Causing Stable Expression of a Foreign Gene Affects General Proteome Pattern in Giardia lamblia Trophozoites
por: Heller, Manfred, et al.
Publicado: (2020)

Purification, concentration and recovery of small fragments of DNA from Giardia lamblia and their use for other molecular techniques
por: Santos, Fabiola, et al.
Publicado: (2017)

Pyrimidine salvage in Giardia lamblia
Publicado: (1985)

Heterogeneity of quaternary structure of glucosamine-6-phosphate deaminase from Giardia lamblia
por: Kwiatkowska-Semrau, Karolina, et al.
Publicado: (2014)

“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”
por: Garzon, Thania, et al.
Publicado: (2021)

Biology of Giardia lamblia. Detection of N-acetyl-D-glucosamine as the only surface saccharide moiety and identification of two distinct subsets of trophozoites by lectin binding
Publicado: (1988)

Purine salvage networks in Giardia lamblia
Publicado: (1983)

Recopilación bibliográfica sobre Giardia Lamblia
por: Cosmes Jiménez, Flora María
Publicado: (1986)

The Proteome Landscape of Giardia lamblia Encystation
por: Faso, Carmen, et al.
Publicado: (2013)

Quinacrine in the Eradication of Giardia Lamblia Infection
por: Pant, K. C., et al.
Publicado: (1942)

Giardia lamblia infections in children in Ghana
por: Anim-Baidoo, Isaac, et al.
Publicado: (2016)

Membrane-Associated Proteins in Giardia lamblia
por: Touz, María C., et al.
Publicado: (2018)

A Lesson in Survival, by Giardia lamblia
por: Rópolo, Andrea A. S., et al.
Publicado: (2010)

Five facts about Giardia lamblia
por: Cernikova, Lenka, et al.
Publicado: (2018)

Modified PEHPS Medium as an Alternative for the In Vitro Culture of Giardia lamblia
por: Vargas-Villarreal, Javier, et al.
Publicado: (2014)

Voltage‐dependent potassium currents expressed in Xenopus laevis oocytes after injection of mRNA isolated from trophozoites of Giardia lamblia (strain Portland‐1)
por: Ponce, Arturo, et al.
Publicado: (2013)

Analysis of Giardia lamblia Nucleolus as Drug Target: A Review
por: Gaona-López, Carlos, et al.
Publicado: (2023)

Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
por: Ansell, Brendan R. E., et al.
Publicado: (2015)

Structural and Functional Perturbation of Giardia lamblia Triosephosphate Isomerase by Modification of a Non-Catalytic, Non-Conserved Region
por: Hernández-Alcántara, Gloria, et al.
Publicado: (2013)

Tonic Shock Induces Detachment of Giardia lamblia
por: Hansen, Wendy R., et al.
Publicado: (2008)

Structure of aldose reductase from Giardia lamblia
por: Ferrell, M., et al.
Publicado: (2011)

Participation of Actin on Giardia lamblia Growth and Encystation
por: Castillo-Romero, Araceli, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_vda9obj9to69s7r618b7o75802