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Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis

Colitis-associated colon cancer (CAC) accompanies the massive infiltration of neutrophils during tumorigenesis and progression of CAC. Depletion of neutrophils in circulation results in significant inhibition of tumor incidence in CAC. However, the underlying mechanisms are largely unclear. In this...

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Detalles Bibliográficos
Autores principales:	Cai, Qing, Kim, Minsun, Harada, Aki, Idowu, Michael O., Sundaresan, Gobalakrishnan, Zweit, Jamal, Oh, Youngman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698049/ https://www.ncbi.nlm.nih.gov/pubmed/36430216 http://dx.doi.org/10.3390/ijms232213737

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