Novel Biomarkers Predictive of Diabetic Charcot Foot—An Overview of the Literature

Background: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. Methods: A review of the original articles published in English, using the “biomarkers AND Charcot’s foot” criterion, resulted in 33 articl...

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Detalles Bibliográficos
Autores principales: Bobircă, Anca, Musetescu, Anca Emanuela, Bordianu, Anca, Pantea Stoian, Anca, Salmen, Teodor, Marinescu, Dan-Cristian, Alexandru, Cristina, Florescu, Alesandra, Radu, Raluca, Isac, Sebastian, Patrascu, Traian, Serban, Dragos, Bobircă, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698200/
https://www.ncbi.nlm.nih.gov/pubmed/36431079
http://dx.doi.org/10.3390/life12111944
Descripción
Sumario:Background: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. Methods: A review of the original articles published in English, using the “biomarkers AND Charcot’s foot” criterion, resulted in 33 articles from the PubMed database and seven articles from the Web of Science database. The five duplicates were eliminated, and two independent reviewers selected the most relevant articles, leaving a total of 21 articles. Results: The biomarkers identified are exhaustively described, related to the system of advanced glycation end products (AGEs) and their soluble receptors (sRAGE), inflammatory cascade, osteoclastogenesis, and, respectively, osteoblastic activity. Conclusions: This article highlights the importance of potential early identifiable biomarkers that can lead to microstructural changes in the affected bones.

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